Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | nicotinic acid|niacin|59-67-6|Pyridine-3-carboxylic acid|3-pyridinecarboxylic acid|vitamin B3|3-Carboxypyridine|wampocap|Niaspan|Acidum nicotinicum|nicolar|Apelagrin|Pellagrin|Akotin|Daskil|Efacin|Pelonin|Linic|nicamin|nicobid|nicocap|Enduracin|Nicodelmin |
|---|---|
| Specifications & Purity | Moligand™, analytical standard, ≥99.5%(HPLC) |
| Storage Temp | Protected from light |
| Shipped In | Normal |
| Grade | analytical standard, Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Agonist of HCA 1 receptor;Agonist of HCA 2 receptor;Agonist of HCA 3 receptor |
Associated Targets
CYP1A2 Tchem Cytochrome P450 1A2 0 Activities
DRD2 Tclin D(2) dopamine receptor 0 Activities
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DRD4 Tchem D(4) dopamine receptor 0 Activities
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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ELANE Tclin Neutrophil elastase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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EGFR Tclin Epidermal growth factor receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HDAC6 Tclin Histone deacetylase 6 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HRH1 Tclin Histamine H1 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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CA2 Tclin Carbonic anhydrase 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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DRD3 Tclin D(3) dopamine receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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XDH Tclin Xanthine dehydrogenase/oxidase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADORA2A Tclin Adenosine receptor A2a 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ACHE Tclin Acetylcholinesterase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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AR Tclin Androgen receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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AKR1B1 Tclin Aldose reductase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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APP Tclin Amyloid-beta A4 protein 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADORA1 Tclin Adenosine receptor A1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADORA3 Tchem Adenosine receptor A3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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EDNRA Tclin Endothelin-1 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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EDNRB Tclin Endothelin receptor type B 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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OPRD1 Tclin Delta-type opioid receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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OPRK1 Tclin Kappa-type opioid receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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OPRM1 Tclin Mu-type opioid receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TACR1 Tclin Substance-P receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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NOS1 Tchem Nitric oxide synthase, brain 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Names and Identifiers
| IUPAC Name | pyridine-3-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9) |
| InChi Key | PVNIIMVLHYAWGP-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CN=C1)C(=O)O |
| Isomeric SMILES | C1=CC(=CN=C1)C(=O)O |
| RTECS | QT0525000 |
| Alternate CAS | 59-67-6,99148-57-9 (tosylate) |
| PubChem CID | 938 |
| NSC Number | 169454 |
| MeSH Entry Terms | 3 Pyridinecarboxylic Acid;3-Pyridinecarboxylic Acid;Aluminum Salt, Niacin;Enduracin;Hydrochloride, Niacin;Induracin;Lithium Nicotinate;Niacin;Niacin Aluminum Salt;Niacin Ammonium Salt;Niacin Calcium Salt;Niacin Cobalt (2+) Salt;Niacin Copper (2+) Salt;Nia |
| Molecular Weight | 123.11 |
| Beilstein | 109591 |
Database links
| PubChem CID | 938 |
|---|---|
| DrugBank Ligand | DB00627 |
| CAS Registry No. | 59-67-6 |
| ChEBI | CHEBI:15940 |
| Wikipedia | Niacin |
| ChEMBL Ligand | CHEMBL573 |
| RCSB PDB Ligand | NIO |
| PEP | niacin |
| DrugCentral Ligand | 2835 |
| GPCRdb Ligand | nicotinic acid |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2218561 | Certificate of Analysis | Dec 18, 2023 | N103654 |
| C2307962 | Certificate of Analysis | Feb 20, 2023 | N103654 |
| E2025055 | Certificate of Analysis | Feb 10, 2022 | N103654 |
Chemical and Physical Properties
| Sensitivity | Light sensitive. |
|---|---|
| Flash Point(°C) | 193°C |
| Melt Point(°C) | 238°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
| RTECS | QT0525000 |
| Merck Index | 6525 |