H2231570
![[³H]nicotinic acid - , used for , CAS No. H614187, by Aladdin Scientific](https://media-prod.aladdinsci.com/media/catalog/product/cache/515ce11dbf2c7bc125424616eb49ad88/s/j/sj_500_H614187.jpg)
Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | P.P. factor-pellagra preventive factor | niacin | vitamin B3 | 3-Picolinic acid | Kyselina nikotinova [Czech] | Niacin (nicotinic acid) | Daskil | Niacin [USP] | S115 | 2679MF687A | Nicosyl | Slo-niacin | CCRIS 1902 | Pyridine-3-carboxylic acid | Apelagri |
|---|---|
| Specifications & Purity | Moligand™, for plant cell culture, ≥99% |
| Storage Temp | Protected from light |
| Shipped In | Normal |
| Grade | for plant cell culture, Moligand™ |
| Product Description | Application： Vitamin of the B complex with hypolipidemic properties occurring in various animal and plant tissues. Required by the body for the formation of coenzymes NAD and NADP.Nicotinic acid is used as an antidyslipidemic agent. It is also used to improve all lipoproteins well above the vitamin requirement and lowers the total cholesterol, "bad" LDL-cholesterol, and triglyceride levels. Further, it is used as a food additive in food industries, cosmetics and pharmaceuticals. In addition to this, it is used in medication, nutrient, enriched flours and in electroplating baths. |
Associated Targets(Human)
HCAR2 Tclin Hydroxycarboxylic acid receptor 2 (14 Activities)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA2 Tclin Carbonic anhydrase II (17698 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ESR1 Tclin Estrogen receptor alpha (17718 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HMGCR Tclin HMG-CoA reductase (2475 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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INSR Tclin Insulin receptor (5558 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PGR Tclin Progesterone receptor (8562 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AR Tclin Androgen Receptor (11781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ACE Tclin Angiotensin-converting enzyme (1423 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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DRD2 Tclin Dopamine D2 receptor (23596 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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TYR Tclin Tyrosinase (717 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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MAOA Tclin Monoamine oxidase A (11911 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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DRD1 Tclin Dopamine D1 receptor (9720 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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DRD4 Tchem Dopamine D4 receptor (7907 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ACHE Tclin Acetylcholinesterase (18204 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HRH2 Tclin Histamine H2 receptor (5428 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
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AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CALCR Tclin Calcitonin receptor (2215 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC6A4 Tclin Serotonin transporter (12625 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HRH1 Tclin Histamine H1 receptor (7573 Activities)
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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
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OPRM1 Tclin Mu opioid receptor (19785 Activities)
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DRD3 Tclin Dopamine D3 receptor (14368 Activities)
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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
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OPRD1 Tclin Delta opioid receptor (15096 Activities)
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OPRK1 Tclin Kappa opioid receptor (16155 Activities)
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HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
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GCGR Tclin Glucagon receptor (2563 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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XDH Tclin Xanthine dehydrogenase (1038 Activities)
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SLC6A3 Tclin Dopamine transporter (10535 Activities)
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Associated Targets(non-human)
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
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Mc4r Melanocortin receptor 4 (1205 Activities)
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Ltc4s Leukotriene C4 synthase (1 Activities)
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Sigmar1 Sigma opioid receptor (160 Activities)
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Npy1r Neuropeptide Y receptor type 1 (8 Activities)
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Cckar Cholecystokinin A receptor (90 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Ntsr1 Neurotensin receptor 1 (48 Activities)
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Pde4d Phosphodiesterase 4D (4 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Bdkrb1 Bradykinin B1 receptor (77 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nos2 Nitric oxide synthase, inducible (3573 Activities)
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Mapk1 MAP kinase ERK2 (650 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Hdac6 Histone deacetylase 6 (222 Activities)
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Mmp9 Matrix metalloproteinase 9 (38 Activities)
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Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Pseudomonas aeruginosa (123386 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Klebsiella pneumoniae (43867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Staphylococcus aureus (210822 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Acinetobacter baumannii (41033 Activities)
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Escherichia coli (133304 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Aspergillus flavus (8875 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mycobacterium tuberculosis variant bovis (1746 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Plasmodium falciparum (966862 Activities)
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Cryptococcus neoformans (21258 Activities)
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Candida albicans (78123 Activities)
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Leishmania donovani (89745 Activities)
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Trypanosoma cruzi (99888 Activities)
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Meloidogyne incognita (862 Activities)
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Canis familiaris (36305 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Trypanosoma brucei rhodesiense (7991 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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L1210 (27553 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RAW264.7 (28094 Activities)
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HT-22 (3261 Activities)
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Fusarium verticillioides (912 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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norA Quinolone resistance protein norA (2171 Activities)
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rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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pfk 6-phospho-1-fructokinase (7870 Activities)
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Plasma (328 Activities)
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Intestine (514 Activities)
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Cat Catalase (15 Activities)
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Slc22a5 Solute carrier family 22 member 5 (44 Activities)
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clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Cenchrus americanus (77 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Glra2 Glycine receptor (1745 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | pyridine-3-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9) |
| InChi Key | PVNIIMVLHYAWGP-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CN=C1)C(=O)O |
| Isomeric SMILES | C1=CC(=CN=C1)C(=O)O |
| RTECS | QT0525000 |
| Alternate CAS | 59-67-6,99148-57-9 (tosylate) |
| PubChem CID | 938 |
| NSC Number | 169454 |
| MeSH Entry Terms | 3 Pyridinecarboxylic Acid;3-Pyridinecarboxylic Acid;Aluminum Salt, Niacin;Enduracin;Hydrochloride, Niacin;Induracin;Lithium Nicotinate;Niacin;Niacin Aluminum Salt;Niacin Ammonium Salt;Niacin Calcium Salt;Niacin Cobalt (2+) Salt;Niacin Copper (2+) Salt;Nia |
| Molecular Weight | 123.11 |
| Beilstein | 109591 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Solubility | 1 M NaOH: soluble 50 mg/mL, clear, colorless to very faintly yellow |
|---|---|
| Sensitivity | Light sensitive |
| Flash Point(°C) | 193°C |
| Melt Point(°C) | 238°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
| RTECS | QT0525000 |
| Merck Index | 6525 |
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FAQs and Articles
Citations of This Product
| 1. Zhi Chen, Zhaohe Dong, Xin Ju, Lishi Yan, Liangzhi Li, Donzhi Wei. (2023) Screening of a novel and thermostable nicotinate dehydrogenase-producing strain Bacillus paramycoides for efficient synthesis of 6-hydroxynicotinic acid. BIOCATALYSIS AND BIOTRANSFORMATION, [PMID:22383884] [10.1080/10242422.2023.2289338] |
| 2. Wang Ting, Zhang Jieyuan, Wu Yue, Wang Shiyi, Jiang Xinhui, Zhang Zhengwei, Li Siqiao. (2023) Smartphone-integrated ratiometric fluorescence sensing platform based on bimetallic metal–organic framework nanowires for anthrax biomarker detection. MICROCHIMICA ACTA, 190 (12): (1-9). [PMID:38006440] [10.1007/s00604-023-06065-7] |
| 3. Yangyang Sun, Zhuzhu Tang, Yanjun Li, Yongkang Song, Hualei Wang, Dongzhi Wei, Shengli Yang. (2024) Identification and evolution of non-traditional nitrilase from Spirosoma linguale DSM 74 with high hydration activity. BIOORGANIC CHEMISTRY, 143 (107055). [PMID:38185008] [10.1016/j.bioorg.2023.107055] |
| 4. Zhipeng Wang, Tingting Ma, Junkai Wang, Shaorun Zhu, Mei Zhang, Min Guo. (2023) Surface passivation for efficient and stable perovskite solar cells in ambient air: The structural effect of amine molecules. CERAMICS INTERNATIONAL, [PMID:] [10.1016/j.ceramint.2023.12.058] |
| 5. Fangfang Li, Yueyue Hu, Yong Cheng, Ying-Hua Zhou. (2024) Design of composite based on UiO-66 and ionic liquid for the CO2 conversion into cyclocarbonate. MICROPOROUS AND MESOPOROUS MATERIALS, 365 (20): (112909). [PMID:20723760] [10.1016/j.micromeso.2023.112909] |
| 6. Xinyu Shao, Lulu Cao, Lixia Lu. (2024) Ultrasensitive detection of glucose oxidase and alkaline phosphatase in milk based on valence regulated upconversion nanoprobes. FOOD CHEMISTRY, 432 (137212). [PMID:37634343] [10.1016/j.foodchem.2023.137212] |
| 7. Ning Han, Yifei Li, Haisen Peng, Ruize Gao, Qiongqiong He, Zhenyong Miao, Keji Wan. (2023) Adsorption of Li+ by imprinted capacitor deionization — A new method for selective recovery of valuable lithium in acidic solutions. DESALINATION, 565 (116820). [PMID:] [10.1016/j.desal.2023.116820] |
| 8. Yu Yangjian, Liu Peng, Wang Fazhou, Hu Chuanlin. (2023) Preparation of Hydrophobic Fly Ash by Surface Modification and Oil-water Separation Devices. JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 38 (3): (695-700). [PMID:] [10.1007/s11595-023-2748-7] |
| 9. Xiao-Dong Cheng, Zheng Zhang, Yun-Ping Li. (2023) A facile approach to undecylenic acid-functionalized stationary phases for per aqueous liquid chromatography. ANALYTICA CHIMICA ACTA, 1265 (341337). [PMID:37230580] [10.1016/j.aca.2023.341337] |
| 10. Chao-ping He, Wen-juan Quan, Ya-ling Zeng, Hong-yan Zhou, Pei-dong You, Zhen-xian Li, Ya-mei Li, Li-mei Lin, Bin Liu, Duan-fang Liao, Qin-hui Tuo. (2023) Construction of nicotinic acid curcumin nanoparticles and its Anti-atherosclerosis effect via PCSK9/LDL-R, ABCA1/Caveolin-1/LXR pathway. MATERIALS & DESIGN, 229 (111931). [PMID:] [10.1016/j.matdes.2023.111931] |
| 11. Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang. (2023) Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin. CRYSTAL GROWTH & DESIGN, 23 (5): (3244–3257). [PMID:] [10.1021/acs.cgd.2c01414] |
| 12. Hengye Li, Xingwei Han, Lin Zhang, Wenjie Yu, Wenwen Bie, Meijie Wei, Zhongxia Wang, Fenying Kong, Wei Wang. (2023) Sulfonated polyhedral oligomeric silsesquioxane-cyclodextrin hybrid polymers for efficient removal of micropollutants from water. CARBOHYDRATE POLYMERS, 312 (120832). [PMID:37059548] [10.1016/j.carbpol.2023.120832] |
| 13. Wenlong Wan, Jie Xu, Jiayuan Shi, Xin Zhang, Anran Wang, Xiaojing Dong, Shuyan Miao. (2023) The interaction of dietary niacin and lipid affects the growth, antioxidant capacity and lipid metabolism of male Eriocheir sinensis. Aquaculture Reports, 30 (101541). [PMID:] [10.1016/j.aqrep.2023.101541] |
| 14. Hengye Li, Xingwei Han, Wenjie Yu, Lin Zhang, Wenwen Bie, Meijie Wei, Zhongxia Wang, Fenying Kong, Wei Wang. (2023) Synthesis of porous dimethoxypillar[5]arene knitted β-cyclodextrin copolymers for efficient adsorption of organic micropollutants. CARBOHYDRATE POLYMERS, 310 (120719). [PMID:36925245] [10.1016/j.carbpol.2023.120719] |
| 15. Xue-Jiao Liu, Bao-Di Ma, Xiao-Mei Wu, Yi Xu. (2023) Highly Efficient Biosynthesis of Nicotinic Acid by Immobilized Whole Cells of E. coli Expressing Nitrilase in Semi-Continuous Packed-Bed Bioreactor. Catalysts, 13 (2): (371). [PMID:] [10.3390/catal13020371] |
| 16. Hongwei Ren, Yize Liu, Ruoyao Zhang, Tengda Zhao, Jing Han, Zhiyang Zheng, Erhong Duan. (2023) Investigation of the CO2 capture behavior in multiple-site natural deep eutectic solvents. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 172 (136). [PMID:] [10.1016/j.psep.2023.01.061] |
| 17. Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan. (2023) Green ratiometric fluorescent dual-mode nanosensor for highly selective and sensitive detection of new coccine in food. DYES AND PIGMENTS, 210 (111024). [PMID:] [10.1016/j.dyepig.2022.111024] |
| 18. Huifang Wu, Mengqi Xu, Yubing Chen, Haoliang Zhang, Yongjun Shen, Yanfeng Tang. (2022) A Highly Sensitive and Selective Nano-Fluorescent Probe for Ratiometric and Visual Detection of Oxytetracycline Benefiting from Dual Roles of Nitrogen-Doped Carbon Dots. Nanomaterials, 12 (23): (4306). [PMID:36500929] [10.3390/nano12234306] |
| 19. Zhiqin Ding, Mengdie Cai, Weimin Gan, Ping Yuan, Lijun Wei, Xianglei Cheng. (2023) Studies on a novel method for the determination of nitrosamines in food by HPLC-UV-FLD coupling with terbium-doped carbon dots. FOOD CHEMISTRY, 405 (134894). [PMID:] [10.1016/j.foodchem.2022.134894] |
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