| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab177848-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
| Ab177848-1mg | 1mg | In stock | $329.90 | |
| Ab177848-5mg | 5mg | In stock | $869.90 | |
| Ab177848-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,379.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Nidanilimab (anti-IL-1R3) - Primary antibody, specific to IL1RAP, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | C3orf13 antibody | FLJ37788 antibody | IL 1 receptor accessory protein antibody | IL 1R 3 antibody | IL 1R3 antibody | IL 1RAcP antibody | IL 1RAP antibody | IL-1 receptor accessory protein antibody | IL-1R-3 antibody | IL-1R3 antibody | IL-1RAcP antibody |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Host species | Human |
| Specificity | IL1RAP |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description | Nidanilimab (anti-IL-1R3) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab (anti-IL-1R3) blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab (anti-IL-1R3) can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC). |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.5 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 160.1 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2171061-85-9 |
Nidanilimab (anti-IL-1R3) (Ab177848) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling IL-1R3 (red) with Nidanilimab (anti-IL-1R3) (Ab177848). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Nidanilimab (anti-IL-1R3) (Ab177848) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling IL-1R3 (red) with Nidanilimab (anti-IL-1R3) (Ab177848). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Nidanilimab (anti-IL-1R3) (Ab177848) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling IL-1R3 (red) with Nidanilimab (anti-IL-1R3) (Ab177848). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Nidanilimab (anti-IL-1R3) (Ab177848) - SEC
The purity of Nidanilimab (anti-IL-1R3) (Ab177848) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1202011 | Certificate of Analysis | Dec 13, 2023 | Ab177848 |
| ZJ23F1202012 | Certificate of Analysis | Dec 13, 2023 | Ab177848 |
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| 14. Lingel, Andreas and 7 more authors.. (2009) Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.. Structure (London, England : 1993), (14): [PMID:19836339] |
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| 19. Xia, Jie J and 8 more authors.. (2015) Increased IL-33 expression in chronic obstructive pulmonary disease.. American journal of physiology. Lung cellular and molecular physiology, (1): [PMID:25595648] |
