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Nidufexor (LMB-763) - 99%, high purity , Bile acid receptor FXR agonist, CAS No.1773489-72-7, Bile acid receptor FXR agonist

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Nidufexor (LMB-763) - 99%, high purity , Bile acid receptor FXR agonist, CAS No.1773489-72-7, Bile acid receptor FXR agonist

Moligand™

≥99%

CAS#: 1773489-72-7
Formula: C₂₇H₂₂ClN₃O₄
Molecular Weight: 487.93
PubChem CID: 118063735

Item Number

N412140

Grouped product items
SKU	Size	Availability	Price	Qty
N412140-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$147.90
N412140-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$666.90

FXR Agonists

View related series

Farnesoid X receptor Agonist

Basic Description

Synonyms	4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid \| NIDUFEXOR [WHO-DD] \| compound 1 [PMID: 31940200] \| DTXSID801336678 \| MFCD31657267 \| CJ1PL0TE6J \| Nidufexor [INN] \| Benzoic acid, 4-[[[(8-chloro-1,4-dihydr
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Bile acid receptor FXR agonist
Product Description	Information Nidufexor (LMB-763) Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR) . Targets FXR

Product Properties

ALogP	4.4

Associated Targets(Human)

NR1H4 Tclin Bile acid receptor (2 Activities)

Discover Target: NR1H4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

Discover Target: PGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

Discover Target: NR1H4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H3 Tchem LXR-alpha (2891 Activities)

Discover Target: NR1H3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1I2 Tchem Pregnane X receptor (6667 Activities)

Discover Target: NR1I2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1723 Activities)

Discover Target: GPBAR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid
INCHI	InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34)
InChi Key	JYTIXGYXBIBOMN-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC=CC=C4)CC5=CC=C(C=C5)C(=O)O
Isomeric SMILES	CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC=CC=C4)CC5=CC=C(C=C5)C(=O)O
PubChem CID	118063735
Molecular Weight	487.93

Database links

PubChem CID	118063735
CAS Registry No.	1773489-72-7

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (204.94 mM); Water: Insoluble; Ethanol: Insoluble;

References

1. Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M et al.. (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.. J Med Chem, 63 (8): (3868-3880). [PMID:31940200] [10.1021/op500134e]

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