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Nidufexor (LMB-763) - 99%, high purity , Bile acid receptor FXR agonist, CAS No.1773489-72-7, Bile acid receptor FXR agonist
Basic Description Synonyms Nidufexor|1773489-72-7|LMB-763|LMB763|Nidufexor [INN]|CJ1PL0TE6J|Benzoic acid, 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-|4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)a Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR). Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Bile acid receptor FXR agonist Product Description Information
Nidufexor (LMB-763) Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR) .
Targets
FXR
Names and Identifiers IUPAC Name 4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid INCHI InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34) InChi Key JYTIXGYXBIBOMN-UHFFFAOYSA-N Canonical SMILES CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC=CC=C4)CC5=CC=C(C=C5)C(=O)O Isomeric SMILES CN1C2=C(COC3=C2C=C(C=C3)Cl)C(=N1)C(=O)N(CC4=CC=CC=C4)CC5=CC=C(C=C5)C(=O)O PubChem CID 118063735 Molecular Weight 487.93
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL (204.94 mM); Water: Insoluble; Ethanol: Insoluble;
References 1. Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M et al. . (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.. J Med Chem, 63 (8): (3868-3880). [PMID:31940200 ]
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