Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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N123275-5g | 5g | In stock | $103.90 | |
N123275-25g | 25g | In stock | $468.90 | |
N123275-100g | 100g | In stock | $1,684.90 | |
N123275-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $7,581.90 |
L-type Ca 2+ channel blocker
Synonyms | nifedipine|21829-25-4|Adalat|Procardia|Procardia XL|Adalat CC|Fenihidine|Citilat|Cordipin|Corinfar|Oxcord|Coracten|Fenihidin|Bay-a-1040|dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|Afeditab CR|Nifediac|Nifedipinum|Adalate| |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | L-type Ca2+ channel blocker; induces apoptosis in human glioblastoma cells.L-type Ca 2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ACTIVATOR, AGONIST, ANTAGONIST, BLOCKER, CHANNEL BLOCKER, GATING INHIBITOR |
Mechanism of action | Voltage-gated L-type calcium channel blocker |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 2.2 |
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IUPAC Name | dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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INCHI | InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 |
InChi Key | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
Isomeric SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
WGK Germany | 1 |
RTECS | US7975000 |
PubChem CID | 4485 |
Molecular Weight | 346.33 |
Reaxy-Rn | 497773 |
PubChem CID | 4485 |
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DrugBank Ligand | DB01115 |
CAS Registry No. | 21829-25-4 |
ChEBI | CHEBI:7565 |
ChEMBL Ligand | CHEMBL193 |
BindingDB Ligand | 50000778 |
Wikipedia | Nifedipine |
NURSA Ligand | 10.1621/RVZMIO1ZLJ |
PEP | nifedipine |
RCSB PDB Ligand | C5U |
DrugCentral Ligand | 1922 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K1926111 | Certificate of Analysis | Sep 08, 2023 | N123275 |
E2424083 | Certificate of Analysis | Jul 26, 2022 | N123275 |
J2220247 | Certificate of Analysis | Jul 26, 2022 | N123275 |
J2220262 | Certificate of Analysis | Jul 26, 2022 | N123275 |
J2220263 | Certificate of Analysis | Jul 26, 2022 | N123275 |
J2220264 | Certificate of Analysis | Jul 26, 2022 | N123275 |
E2112099 | Certificate of Analysis | May 17, 2021 | N123275 |
E2112100 | Certificate of Analysis | May 17, 2021 | N123275 |
E2112101 | Certificate of Analysis | May 17, 2021 | N123275 |
E2112102 | Certificate of Analysis | May 17, 2021 | N123275 |
Solubility | Soluble in acetone, methylene chloride, chloroform, ethyl acetate, dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water. |
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Sensitivity | Light sensitive |
Melt Point(°C) | 171°C-175°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 1 |
RTECS | US7975000 |
Reaxy-Rn | 497773 |
Merck Index | 6528 |
1. Wang T et al.. (2019) Allopregnanolone Modulates GABAAR-Dependent CaMKIId3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.. Front Cell Neurosci, 13 (569). [PMID:31998078] |
2. Favuzzi E et al.. (2017) Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.. Neuron, 95 (3): (639-655.e10). [PMID:28712654] |
3. Mukherjee S et al.. (2013) Ca2+ oscillations, Ca2+ sensitization, and contraction activated by protein kinase C in small airway smooth muscle.. J Gen Physiol, 141 (2): (165-78). [PMID:23359281] |
4. Pandey A & Sikdar SK. (2014) Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum.. J Physiol, 592 (Pt 16): (3537-57). [PMID:24907304] |
5. Ramachandra R et al.. (2013) Identification of CaV channel types expressed in muscle afferent neurons.. J Neurophysiol, 110 (7): (1535-43). [PMID:23843437] |
6. Brandalise F & Gerber U. (2014) Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses.. Proc Natl Acad Sci U S A, 111 (11): (4303-8). [PMID:24550458] |
7. Ferreira SG et al.. (2009) N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.. Neuropharmacology, 56 (3): (676-83). [PMID:19101577] |
8. Wong E et al.. (2022) Phototransduction in a marine sponge provides insights into the origin of animal vision.. iScience, 25 (6): (104436). [PMID:35707725] |
9. Zhang F & Tzanakakis ES. (2017) Optogenetic regulation of insulin secretion in pancreatic ß-cells.. Sci Rep, 7 (9357). [PMID:28839233] |
10. Toft-Bertelsen TL et al.. (2016) Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.. Mol Biol Cell, 27 (21): (3329-3341). [PMID:27605709] |
11. Ahmed T et al.. (2015) Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.. Neurobiol Aging, 36 (2): (730-9). [PMID:25443285] |
12. Nguyen Ngoc TD et al.. (2012) Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways.. Toxicol Appl Pharmacol, 259 (3): (329-37). [PMID:22285274] |