Niflumic acid - >98.0%(HPLC), high purity , CAS No.4394-00-7, Channel blocker of CaCC;Channel blocker of ClC-1;Activator of ClC-Ka;Channel blocker of ClC-Ka;Activator of ClC-Kb;Activator of K Na1.2;Activator of K v7.1;Activator of TRPA1;Channel blocker of TRPC4

Item Number

N129597

• Synonyms: niflumic acid | 4394-00-7 | Landruma | Nifluril | Forenol | Nifluminic acid | 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid | Niflugel | Acido niflumico | Acide niflumique | UP 83 | Acide niflumique [INN-French] | Acido niflumico [INN-Spanish] | Acidum niflumicum
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Selective cyclooxygenase-2 (COX-2) inhibitor.A NSAID and potent anion channel blocker. Selective COX-2 and CLCA (Ca 2+ -activated Cl - ion channel) inhibitor. Inhibits goblet cell metaplasia and blocks T-currents in mouse spermatogenic cells.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR, CHANNEL BLOCKER
• Mechanism of action: Channel blocker of CaCC;Channel blocker of ClC-1;Activator of ClC-Ka;Channel blocker of ClC-Ka;Activator of ClC-Kb;Activator of K Na1.2;Activator of K v7.1;Activator of TRPA1;Channel blocker of TRPC4
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Application：
Niflumic acid has been used:
as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements, to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction.

as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC).
as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells.