Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N129550-100mg | 100mg | In stock | $24.90 | |
N129550-500mg | 500mg | In stock | $103.90 | |
N129550-5g | 5g | In stock | $936.90 | |
N129550-25g | 25g | In stock | $4,212.90 | |
N129550-100g | 100g | In stock | $15,163.90 |
JAK/STAT signaling inhibitor. Nitrofuran antibiotic.
Synonyms | SCHEMBL543480 | 4-hydroxy-N'-[(5-nitrofuran-2-yl)methylidene]benzohydrazide | NIFUROXAZIDE [MART.] | PM5LI0P38J | AS-13310 | CS-4918 | EN300-21037331 | Ercefuryl | 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylidene]benzenecarbohydrazonic acid | Benzoic acid, |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells dependin |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | An inhibitor of STAT activation and signaling activity |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide |
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INCHI | InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+ |
InChi Key | YCWSUKQGVSGXJO-NTUHNPAUSA-N |
Canonical SMILES | C1=CC(=CC=C1C(=O)NN=CC2=CC=C(O2)[N+](=O)[O-])O |
Isomeric SMILES | C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O |
WGK Germany | 3 |
PubChem CID | 5337997 |
Molecular Weight | 275.22 |
Antibiotic DB | 1983 |
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PubChem CID | 5337997 |
ChEMBL Ligand | CHEMBL244888 |
ChEBI | CHEBI:135136 |
DrugBank Ligand | DB13855 |
CAS Registry No. | 965-52-6 |
Wikipedia | Nifuroxazide |
DrugCentral Ligand | 1928 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2320842 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2320910 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2320925 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2320944 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2320965 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2320966 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2321155 | Certificate of Analysis | Mar 16, 2023 | N129550 |
D2321164 | Certificate of Analysis | Mar 16, 2023 | N129550 |
G1524097 | Certificate of Analysis | Feb 06, 2023 | N129550 |
Solubility | Soluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO. |
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Sensitivity | Light Sensitive,Air Sensitive,Heat Sensitive |
Melt Point(°C) | 281-283°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed H336:May cause drowsiness or dizziness H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
WGK Germany | 3 |
Merck Index | 6535 |
1. Cevik UA, Saglik BN, Ozkay Y, Canturk Z, Bueno J, Demirci F, Koparal AS. (2017) Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates.. Curr Pharm Des, 23 (15): (2276-2286). [PMID:27908268] [10.1021/op500134e] |
2. Bailly C. (2019) Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment.. Drug Discov Today, 24 (9): (1930-1936). [PMID:31260646] [10.1021/op500134e] |