Niguldipine hydrochloride , CAS No.113317-61-6

Item Number

N335260

• Synonyms: 3-Methyl 5-[3-(4,4-diphenyl-1-piperidinyl)-propyl] (-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate hydrochloride | J-002947 | NCGC00025014-03 | 3-(3-(4,4-Diphenylpiperidin-1-yl)propyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-
• Storage Temp: Room temperature
• Shipped In: Normal

Product Description

Niguldipine HCl has been reported to be a highly selective α|1|-adrenoceptor antagonist and dihydropyridine calcium channel blocker. More specifically, Niguldipine HCl has been shown to irreversibly inhibit T-type calcium channel currents in certain types of central and peripheral neurons and in smooth muscle cells. This compound has also been noted to inhibit noradrenaline-stimulated inositol phosphate accumulation. Additional reports demonstrate that Niguldipine HCl can potently and specifically inhibit bTREK-1 (IC|50|= 5.07μM). Niguldipine HCl is an inhibitor of Mdr-1.