Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N129505-1g | 1g | In stock | $76.90 |
Potent L-type calcium channel blocker
Synonyms | nilvadipine | 75530-68-6 | Escor | Nivadil | Nivadipine | FR-34235 | FK 235 | Nivadip | Dl-nilvadipine | FR 34235 | SK&F 102,362 | CL 287,389 | FK-235 | CL-287389 | Nilvadipine (ARC029) | 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | SK& |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Nilvadipine is a potent calcium channel blocker that is used for treatment of hypertension. Nilvadipine, as other dihydropyridine calcium antagonists, decreases intracellular calcium concentration causing dilation of the coronary and systemic arteries. Ni |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM. |
ALogP | 2.9 |
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Pubchem Sid | 488179838 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179838 |
IUPAC Name | 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
INCHI | InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3 |
InChi Key | FAIIFDPAEUKBEP-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C |
Isomeric SMILES | CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C |
WGK Germany | 3 |
RTECS | US7968300 |
Alternate CAS | 75530-68-6 |
PubChem CID | 4494 |
MeSH Entry Terms | 5-isopropyl-3-methyl-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinecarboxylate;Escor;FR 34235;FR-34235;nilvadipine;Nivadil |
Molecular Weight | 385.37 |
Reaxy-Rn | 3572609 |
PubChem SID | 488179838 |
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Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2326958 | Certificate of Analysis | May 04, 2023 | N129505 |
D2326961 | Certificate of Analysis | May 04, 2023 | N129505 |
D2313205 | Certificate of Analysis | Mar 02, 2023 | N129505 |
D2313206 | Certificate of Analysis | Mar 02, 2023 | N129505 |
Solubility | Soluble in Ethanol |
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Melt Point(°C) | 148-150°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | US7968300 |
Reaxy-Rn | 3572609 |
Merck Index | 6545 |
Starting at $173.90