Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N159746-1g | 1g | In stock | $19.90 | |
N159746-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $85.90 | |
N159746-25g | 25g | In stock | $384.90 | |
N159746-100g | 100g | In stock | $1,385.90 |
Selective COX-2 NSAID
Synonyms | HMS502C15 | N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide | N-(4-nitro-2-phenoxy-phenyl)methanesulfonamide | NIMESULIDE (MART.) | NIMESULIDE [EP MONOGRAPH] | NINDS_000693 | SPBio_001382 | BCBcMAP01_000034 | Prestwick1_000194 | Bio2_000382 | GTPL7401 | NIM |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Selective cyclooxygenase-2 (COX-2) inhibitor. Analgesic, anti-inflammatory and antipyretic activities in vivo . Orally activ |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-(4-nitro-2-phenoxyphenyl)methanesulfonamide |
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INCHI | InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3 |
InChi Key | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
Canonical SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 |
Isomeric SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 |
WGK Germany | 3 |
RTECS | PB0970000 |
PubChem CID | 4495 |
Molecular Weight | 308.31 |
ChEMBL Ligand | CHEMBL56367 |
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DrugBank Ligand | DB04743 |
PubChem CID | 4495 |
CAS Registry No. | 51803-78-2 |
Wikipedia | Nimesulide |
RCSB PDB Ligand | NIM |
DrugCentral Ligand | 1935 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2221544 | Certificate of Analysis | Jul 27, 2022 | N159746 |
J2221572 | Certificate of Analysis | Jul 27, 2022 | N159746 |
C1829117 | Certificate of Analysis | Jan 22, 2022 | N159746 |
C1829118 | Certificate of Analysis | Jan 22, 2022 | N159746 |
Solubility | Soluble in Dimethylformamide |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 150 °C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H302:Harmful if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | PB0970000 |
Merck Index | 6548 |
Starting at $399.90
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Starting at $154.90
1. Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun. (2021) Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 269 (115161). [PMID:] |
2. Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu. (2021) Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation. SEPARATION AND PURIFICATION TECHNOLOGY, 264 (118288). [PMID:] |
3. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796] |
4. Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG. (2020) On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet. ANALYTICAL SCIENCES, 36 (11): (1379-1385). [PMID:32655105] |
5. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu. (2020) A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states. SENSORS AND ACTUATORS B-CHEMICAL, 324 (128696). [PMID:] |
6. Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng. (2020) Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide. CHEMICAL ENGINEERING JOURNAL, 381 (122517). [PMID:] |
1. Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun. (2021) Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 269 (115161). [PMID:] |
2. Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu. (2021) Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation. SEPARATION AND PURIFICATION TECHNOLOGY, 264 (118288). [PMID:] |
3. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796] |
4. Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG. (2020) On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet. ANALYTICAL SCIENCES, 36 (11): (1379-1385). [PMID:32655105] |
5. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu. (2020) A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states. SENSORS AND ACTUATORS B-CHEMICAL, 324 (128696). [PMID:] |
6. Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng. (2020) Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide. CHEMICAL ENGINEERING JOURNAL, 381 (122517). [PMID:] |