Basic Description

Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Nimesulide is a relativelyCOX-2selective inhibitor withIC50of 26 μM. In vitro In vivo Cell Data cell lines：HepG2 cells Concentrations： Incubation Time： Powder Purity:≥99%

Associated Targets(Human)

SLC6A19 Tchem Sodium-dependent neutral amino acid transporter B(0)AT1 (1 Activities)

Discover Target: SLC6A19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (8 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Canonical SMILES	C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
Molecular Weight	308.31

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 66 mg/mL (198.11 mM); Ethanol: -1 mg/mL

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun. (2021) Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 269 (115161). [PMID:]
2. Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu. (2021) Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation. SEPARATION AND PURIFICATION TECHNOLOGY, 264 (118288). [PMID:]
3. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796]
4. Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG. (2020) On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet. ANALYTICAL SCIENCES, 36 (11): (1379-1385). [PMID:32655105]
5. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu. (2020) A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states. SENSORS AND ACTUATORS B-CHEMICAL, 324 (128696). [PMID:]
6. Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng. (2020) Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide. CHEMICAL ENGINEERING JOURNAL, 381 (122517). [PMID:]

References

1. Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun. (2021) Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 269 (115161). [PMID:]
2. Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu. (2021) Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation. SEPARATION AND PURIFICATION TECHNOLOGY, 264 (118288). [PMID:]
3. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796]
4. Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG. (2020) On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet. ANALYTICAL SCIENCES, 36 (11): (1379-1385). [PMID:32655105]
5. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu. (2020) A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states. SENSORS AND ACTUATORS B-CHEMICAL, 324 (128696). [PMID:]
6. Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng. (2020) Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide. CHEMICAL ENGINEERING JOURNAL, 381 (122517). [PMID:]

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Nimesulide - 10mM in DMSO, high purity , CAS No.51803-78-2(DMSO)