Nimodipine - ≥98%, high purity , CAS No.66085-59-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
Nimodipine - ≥98%, high purity , CAS No.66085-59-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
nimodipine|66085-59-4|Nimotop|Periplum|Admon|Nimodipino|Nimodipinum|Nymalize|BAY e 9736|Bay-e-9736|nemotan|Bay-E 9736|Nimodipinum [INN-Latin]|Nimodipino [INN-Spanish]|Nimodipine ap|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-py
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.L-type Ca 2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine.
Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy An L-type calcium channel protein inhibitor
Soluble in methanol (62.5 mg/ml), DMSO (25 mg/ml), dioxane, water (24.3 mg/L) at 25 °C, and ethanol (10 mM). Insoluble in 2-hydroxypropyl-b-cyclodextrin.
1.Wheeler DG et al.. (2012) Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression.. Cell, 149 (5):(1112-24). [PMID:22632974]
2.Han KS et al.. (2018) Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.. Neuron, 100 (3):(564-578.e3). [PMID:30293822]
3.Cohen SM et al.. (2015) Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.. Biochem Biophys Res Commun, 460 (88-99). [PMID:25998737]
4.Pousinha PA et al.. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.. Cell Rep, 29 (2):(317-331.e5). [PMID:31597094]
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