Grouped product items

SKU

Size

Availability

Price

Qty

N129506-250mg

250mg

Available within 4-8 weeks(?)

$9.90

N129506-1g

Available within 4-8 weeks(?)

$25.90

N129506-5g

Available within 4-8 weeks(?)

$36.90

N129506-25g

25g

In stock

$162.90

Basic Description

Synonyms	Nimodipine ap \| SPECTRUM1503600 \| 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate \| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester \| DTXCID0033
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.L-type Ca 2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ACTIVATOR, ALLOSTERIC MODULATOR, ANTAGONIST, GATING INHIBITOR
Mechanism of action	Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy An L-type calcium channel protein inhibitor

Associated Targets(Human)

CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (0 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C2 Tclin Mineralocorticoid receptor (1 Activities)

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (1 Activities)

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (0 Activities)

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F (1 Activities)

Discover Target: CACNA1F

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1S Tclin Voltage-dependent L-type calcium channel subunit alpha-1S (1 Activities)

Discover Target: CACNA1S

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX4 Tchem P2X purinoceptor 4 (0 Activities)

Discover Target: P2RX4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)

Discover Target: RAPGEF4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cruzipain (33337 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INCHI	InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChi Key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
Isomeric SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
WGK Germany	1
RTECS	US7975500
PubChem CID	4497
Molecular Weight	418.44
Reaxy-Rn	459792

Database links

PubChem CID	4497
ChEBI	CHEBI:7575
ChEMBL Ligand	CHEMBL1428
DrugBank Ligand	DB00393
BindingDB Ligand	50011690
Wikipedia	Nimodipine
CAS Registry No.	66085-59-4
PEP	nimodipine
DrugCentral Ligand	1937

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
F2221291	Certificate of Analysis	Apr 03, 2024	N129506
F2221407	Certificate of Analysis	Apr 03, 2024	N129506
F2118342	Certificate of Analysis	Apr 11, 2023	N129506
G1524098	Certificate of Analysis	Feb 06, 2023	N129506

Chemical and Physical Properties

Solubility	Soluble in methanol (62.5 mg/ml), DMSO (25 mg/ml), dioxane, water (24.3 mg/L) at 25 °C, and ethanol (10 mM). Insoluble in 2-hydroxypropyl-b-cyclodextrin.
Melt Point(°C)	125°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	US7975500
Reaxy-Rn	459792
Merck Index	6551

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ting Ma, Geng Ou. (2023) Fabrication of a highly sensitive electrochemical sensor for the rapid detection of nimodipine. International Journal of Electrochemical Science, 18 (100018). [PMID:]
2. Qiyao Wang, Difan Zhang, Jiani Lu, Jiaying Zhang, Zhenquan Xuan, Luyun Gong, Mengxiang Yang, Lingli Jin, Jingyang Le, An Zhu, Hongze Liang, C. Benjamin Naman, Jinrong Zhang, Li Zhao, Shan He, Qinwen Wang, Hao Liu, Xiaojun Yan, Lingling Zhao, Wei Cui. (2022) PLGA-PEG-fucoxanthin nanoparticles protect against ischemic stroke in vivo. Journal of Functional Foods, 99 (105359). [PMID:]
3. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin. (2021) Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach. ANALYTICAL CHEMISTRY, 93 (24): (8536–8543). [PMID:34107211]
4. Liu Wei, Wang Ruya, Hu Fan, Wu Pinping, Huang Tao, Fizir Meriem, He Hua. (2018) Novel mixed hemimicelles based on nonionic surfactant–imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (28): (7357-7371). [PMID:30294762]
5. Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin. (2017) Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 40 (22): (4311-4319). [PMID:28884956]

References

1. Wheeler DG et al.. (2012) Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression.. Cell, 149 (5): (1112-24). [PMID:22632974]
2. Han KS et al.. (2018) Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.. Neuron, 100 (3): (564-578.e3). [PMID:30293822]
3. Cohen SM et al.. (2015) Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.. Biochem Biophys Res Commun, 460 (88-99). [PMID:25998737]
4. Pousinha PA et al.. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.. Cell Rep, 29 (2): (317-331.e5). [PMID:31597094]
5. Ting Ma, Geng Ou. (2023) Fabrication of a highly sensitive electrochemical sensor for the rapid detection of nimodipine. International Journal of Electrochemical Science, 18 (100018). [PMID:]
6. Qiyao Wang, Difan Zhang, Jiani Lu, Jiaying Zhang, Zhenquan Xuan, Luyun Gong, Mengxiang Yang, Lingli Jin, Jingyang Le, An Zhu, Hongze Liang, C. Benjamin Naman, Jinrong Zhang, Li Zhao, Shan He, Qinwen Wang, Hao Liu, Xiaojun Yan, Lingling Zhao, Wei Cui. (2022) PLGA-PEG-fucoxanthin nanoparticles protect against ischemic stroke in vivo. Journal of Functional Foods, 99 (105359). [PMID:]
7. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin. (2021) Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach. ANALYTICAL CHEMISTRY, 93 (24): (8536–8543). [PMID:34107211]
8. Liu Wei, Wang Ruya, Hu Fan, Wu Pinping, Huang Tao, Fizir Meriem, He Hua. (2018) Novel mixed hemimicelles based on nonionic surfactant–imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (28): (7357-7371). [PMID:30294762]
9. Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin. (2017) Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 40 (22): (4311-4319). [PMID:28884956]

Solution Calculators

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Nimodipine - ≥98%, high purity , CAS No.66085-59-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
N129506-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
N129506-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$25.90
N129506-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$36.90
N129506-25g	25g	In stock	$162.90