Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N125589-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $28.90 | |
N125589-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $113.90 | |
N125589-5g | 5g | In stock | $513.90 | |
N125589-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,308.90 |
L-type Ca 2+ channel blocker
Synonyms | nisoldipine|63675-72-9|Sular|Nisocor|Baymycard|Nisoldipin|Zadipina|Nisoldipino|Nisoldipinum|Syscor|Bay k 5552|3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|Nisoldipinum [INN-Latin]|Nisoldipino [INN-Spanish]|Bay-k |
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Specifications & Purity | ≥98.0 % |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | GATING INHIBITOR |
Mechanism of action | Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3 |
Product Description | Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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INCHI | InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3 |
InChi Key | VKQFCGNPDRICFG-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
Isomeric SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
WGK Germany | 3 |
RTECS | US7975600 |
PubChem CID | 4499 |
Molecular Weight | 388.41 |
PubChem CID | 4499 |
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ChEMBL Ligand | CHEMBL1726 |
DrugBank Ligand | DB00401 |
BindingDB Ligand | 50011689 |
Wikipedia | Nisoldipine |
CAS Registry No. | 63675-72-9 |
PEP | nisoldipine |
DrugCentral Ligand | 1942 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2309108 | Certificate of Analysis | Oct 16, 2023 | N125589 |
K2309200 | Certificate of Analysis | Oct 16, 2023 | N125589 |
K2309201 | Certificate of Analysis | Oct 16, 2023 | N125589 |
B1528013 | Certificate of Analysis | Sep 19, 2022 | N125589 |
Solubility | Soluble in Chloroform and Ethanol |
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Melt Point(°C) | 153 °C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H312:Harmful in contact with skin H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | US7975600 |
Merck Index | 6565 |