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Nisoldipine - ≥98.0 %, high purity , CAS No.63675-72-9, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3

Moligand™

≥98%

CAS#: 63675-72-9
Formula: C₂₀H₂₄N₂O₆
Molecular Weight: 388.41
EC Number: 264-407-7
MDL number: MFCD00478055
PubChem CID: 4499

Item Number

N125589

Grouped product items
SKU	Size	Availability	Price
N125589-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$28.90
N125589-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$113.90
N125589-5g	5g	In stock	$513.90
N125589-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,308.90

L-type Ca 2+ channel blocker

View related series

Calcium Channel Cav1.2 Gating inhibitor Cav1.3 Gating inhibitor Immunology/Inflammation Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling NF-κB Reactive Oxygen Species

Basic Description

Synonyms	CCG-100894 \| CS-1131 \| HMS2093F15 \| HMS2231L20 \| NCGC00164633-03 \| NISOLDIPINE [INN] \| BIDD:GT0684 \| NCGC00164633-02 \| NISOLDIPINE [JAN] \| Nisoldipine SR \| (.+/-.)-Nisoldipine \| (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridined
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Nisoldipine is a calcium channel protein inhibitor.L-type Ca 2+ channel blocker. Ca 2+ antagonist and vasodilator. Cardioprotective. Active in vitro and in vivo .
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	GATING INHIBITOR
Mechanism of action	Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. A calcium channel protein inhibitor.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (2 Activities)

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (0 Activities)

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INCHI	InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChi Key	VKQFCGNPDRICFG-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Isomeric SMILES	CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
WGK Germany	3
RTECS	US7975600
PubChem CID	4499
Molecular Weight	388.41

PubChem CID

ChEMBL Ligand

DrugBank Ligand

BindingDB Ligand

Wikipedia

CAS Registry No.

PEP

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
K2309108	Certificate of Analysis	Oct 16, 2023	N125589
K2309200	Certificate of Analysis	Oct 16, 2023	N125589
K2309201	Certificate of Analysis	Oct 16, 2023	N125589
B1528013	Certificate of Analysis	Sep 19, 2022	N125589

Solubility

Soluble in Chloroform and Ethanol

Melt Point(°C)

153 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Warning
Hazard Statements	H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H312:Harmful in contact with skin H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help.
WGK Germany	3
RTECS	US7975600
Merck Index	6565

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