Potent and selective norepinephrine reuptake (NET) inhibitor (K i values are 0.46, 158 and 505 nM for NET, SERT and DAT, respectively).
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product description：
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels.
Application：
Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.
Associated Targets(Human)
SIRT5TchemNAD-dependent protein deacylase sirtuin-5, mitochondrial (0 Activities)
1.Wei Dong, Qin Zhou, Wangqiang Shen, Le Yang, Peng Jin, Xing Lu, Yongfu Lian. (2023) The Various Packing Structures of Tb@C82 (I, II) Isomers in Their Cocrystals with Ni(OEP). Nanomaterials, 13 (6):(994). [PMID:36985888]
References
1.Wei Dong, Qin Zhou, Wangqiang Shen, Le Yang, Peng Jin, Xing Lu, Yongfu Lian. (2023) The Various Packing Structures of Tb@C82 (I, II) Isomers in Their Cocrystals with Ni(OEP). Nanomaterials, 13 (6):(994). [PMID:36985888]
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