Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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N159057-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
N159057-1g | 1g | In stock | $13.90 | |
N159057-5g | 5g | In stock | $19.90 | |
N159057-25g | 25g | In stock | $29.90 | |
N159057-50g | 50g | In stock | $51.90 | |
N159057-250g | 250g | In stock | $209.90 |
Broad spectrum antiparasitic, antibacterial agent
Synonyms | Nitazoxamide | Nitazoxanida [INN-Spanish] | Nitazoxanidum | Nitazoxanidum [INN-Latin] | Alinia | Nitazoxanida | 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate | 2-((5-nitrothiazol-2-yl)carbamoyl)phenyl acetate | Daxon |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria. It has anti-viral property and effectively halts entry and release of chikungunya virus in in |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | Pyruvate:ferredoxin oxidoreductase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description |
Nitazoxanide, an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model.
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ALogP | 2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate |
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INCHI | InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17) |
InChi Key | YQNQNVDNTFHQSW-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-] |
Isomeric SMILES | CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-] |
WGK Germany | 3 |
PubChem CID | 41684 |
Molecular Weight | 307.28 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2412205 | Certificate of Analysis | Jul 29, 2024 | N159057 |
K1926105 | Certificate of Analysis | Sep 08, 2023 | N159057 |
L1906012 | Certificate of Analysis | Sep 07, 2023 | N159057 |
C2222128 | Certificate of Analysis | Feb 18, 2022 | N159057 |
C2222145 | Certificate of Analysis | Feb 18, 2022 | N159057 |
C2222153 | Certificate of Analysis | Feb 18, 2022 | N159057 |
C2222223 | Certificate of Analysis | Feb 18, 2022 | N159057 |
C2222226 | Certificate of Analysis | Feb 18, 2022 | N159057 |
Solubility | DMSO : ≥ 100 mg/mL (325.44 mM) |
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Sensitivity | heat sensitive |
Melt Point(°C) | 198.0 - 202.0 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Merck Index | 6567 |
1. Zhanding Cui, Dengliang Li, Yinli Xie, Kai Wang, Ying Zhang, Guohua Li, Qian Zhang, Xiaoxueying Chen, Yue Teng, Shihui Zhao, Jiang Shao, Fan Xingmeng, Yanli Zhao, Dongju Du, Yanbing Guo, Hailong Huang, Hao Dong, Guixue Hu, Shuang Zhang, Yongkun Zhao. (2020) Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro. ANTIVIRAL RESEARCH, 182 (104827). [PMID:32579897] [10.1016/j.antiviral.2020.104827] |
1. Zhanding Cui, Dengliang Li, Yinli Xie, Kai Wang, Ying Zhang, Guohua Li, Qian Zhang, Xiaoxueying Chen, Yue Teng, Shihui Zhao, Jiang Shao, Fan Xingmeng, Yanli Zhao, Dongju Du, Yanbing Guo, Hailong Huang, Hao Dong, Guixue Hu, Shuang Zhang, Yongkun Zhao. (2020) Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro. ANTIVIRAL RESEARCH, 182 (104827). [PMID:32579897] [10.1016/j.antiviral.2020.104827] |