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Nitisinone - ≥97%, high purity , 4-hydroxyphenylpyruvate dioxygenase inhibitor, CAS No.104206-65-7, 4-hydroxyphenylpyruvate dioxygenase inhibitor
Basic Description Synonyms FT-0672739 | NITISINONE [MART.] | 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione | 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione;Nitisinone | NCI60_038570 | Orfadin (TN) | RB3134 | Q3877355 | SY047291 | 2-(2-nitro-4-trifluoromet Specifications & Purity Moligand™, ≥97% Biochemical and Physiological Mechanisms Biochem/physiol Actions
Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into ha Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action 4-hydroxyphenylpyruvate dioxygenase inhibitor Product Description Application:
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488187526 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488187526 IUPAC Name 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione INCHI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2 InChi Key OUBCNLGXQFSTLU-UHFFFAOYSA-N Canonical SMILES C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-] Isomeric SMILES C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-] WGK Germany 3 PubChem CID 115355 Molecular Weight 329.23
Chemical and Physical Properties Solubility DMSO: ≥5 mg/mL Sensitivity Heat sensitive Melt Point(°C) 138 °C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H311: Toxic in contact with skin
H302: Harmful if swallowed
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P361+P364: Take off immediately all contaminated clothing and wash it before reuse.
P301+P317: IF SWALLOWED: Get medical help.
P316: Get emergency medical help immediately.
WGK Germany 3
Citations of This Product 1. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707 ] [10.1021/acs.analchem.2c04614 ]
References 1. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707 ] [10.1021/acs.analchem.2c04614 ]
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H2203658