Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N123276-25mg | 25mg | In stock | $46.90 | |
N123276-100mg | 100mg | In stock | $155.90 | |
N123276-500mg | 500mg | In stock | $378.90 | |
N123276-1g | 1g | In stock | $587.90 | |
N123276-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,646.90 | |
N123276-25g | 25g | In stock | $11,907.90 |
L-type Ca 2+ channel blocker
Synonyms | HMS3675I14 | KBio1_001782 | MLS001148149 | 9B627AW319 | BSPBio_000792 | Nitrendipine [USAN:INN:BAN:JAN] | Spectrum2_001565 | MLS002154060 | NITRENDIPINE [USAN] | ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 3,5-Pyrid |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Ca2+ channel blocker; anti-hypertensive. |
Storage Temp | Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER, GATING INHIBITOR |
Mechanism of action | Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ca2+ channel blocker;anti-hypertensive. |
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IUPAC Name | 5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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INCHI | InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3 |
InChi Key | PVHUJELLJLJGLN-UHFFFAOYSA-N |
Canonical SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C |
Isomeric SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C |
WGK Germany | 1 |
RTECS | US5653000 |
PubChem CID | 4507 |
Molecular Weight | 360.36 |
PubChem CID | 4507 |
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ChEBI | CHEBI:553570 |
ChEMBL Ligand | CHEMBL475534 |
DrugBank Ligand | DB01054 |
BindingDB Ligand | 50012016 |
Wikipedia | Nitrendipine |
CAS Registry No. | 39562-70-4 |
DrugCentral Ligand | 1947 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2419442 | Certificate of Analysis | Nov 24, 2023 | N123276 |
D2419444 | Certificate of Analysis | Nov 24, 2023 | N123276 |
D2419445 | Certificate of Analysis | Nov 24, 2023 | N123276 |
D2419446 | Certificate of Analysis | Nov 24, 2023 | N123276 |
D2419447 | Certificate of Analysis | Nov 24, 2023 | N123276 |
H1426034 | Certificate of Analysis | Jun 20, 2022 | N123276 |
E1414040 | Certificate of Analysis | Mar 29, 2022 | N123276 |
D2126307 | Certificate of Analysis | May 06, 2021 | N123276 |
F2303013 | Certificate of Analysis | May 06, 2021 | N123276 |
Solubility | DMSO: soluble17.5 mg/mL H2O: insoluble methanol: soluble15 mg/mL |
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Sensitivity | light & air sensitive |
Melt Point(°C) | 159 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 1 |
RTECS | US5653000 |
Merck Index | 6576 |