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Nitrendipine - ≥95.0%, high purity , CAS No.39562-70-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1
L-type Ca 2+ channel blocker
Basic Description Synonyms HMS3675I14 | KBio1_001782 | MLS001148149 | 9B627AW319 | BSPBio_000792 | Nitrendipine [USAN:INN:BAN:JAN] | Spectrum2_001565 | MLS002154060 | NITRENDIPINE [USAN] | ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 3,5-Pyrid Specifications & Purity Moligand™, ≥95% Biochemical and Physiological Mechanisms Ca2+ channel blocker; anti-hypertensive. Storage Temp Argon charged Shipped In Normal Grade Moligand™ Action Type CHANNEL BLOCKER, GATING INHIBITOR Mechanism of action Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1 Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Ca2+ channel blocker;anti-hypertensive.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate INCHI InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3 InChi Key PVHUJELLJLJGLN-UHFFFAOYSA-N Canonical SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C Isomeric SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C WGK Germany 1 RTECS US5653000 PubChem CID 4507 Molecular Weight 360.36
Chemical and Physical Properties Solubility DMSO: soluble17.5 mg/mL H2O: insoluble methanol: soluble15 mg/mL Sensitivity light & air sensitive Melt Point(°C) 159 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H312: Harmful in contact with skin
H332: Harmful if inhaled
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P362+P364: Take off contaminated clothing and wash it before reuse.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
WGK Germany 1 RTECS US5653000 Merck Index 6576
Citations of This Product 1. Xiuling Tang, Huanhuan Zhao, Wei Jiang, Song Zhang, Shun Guo, Xiaobo Gao, Peng Yang, Lei Shi, Linna Liu. (2018) Pharmacokinetics and pharmacodynamics of citrus peel extract in lipopolysaccharide-induced acute lung injury combined with Pinelliae Rhizoma Praeparatum. Food & Function, 9 (11): (5880-5890). [PMID:30374490 ] [10.1039/C8FO01337C ]
References 1. Xiuling Tang, Huanhuan Zhao, Wei Jiang, Song Zhang, Shun Guo, Xiaobo Gao, Peng Yang, Lei Shi, Linna Liu. (2018) Pharmacokinetics and pharmacodynamics of citrus peel extract in lipopolysaccharide-induced acute lung injury combined with Pinelliae Rhizoma Praeparatum. Food & Function, 9 (11): (5880-5890). [PMID:30374490 ] [10.1039/C8FO01337C ]
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