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NKG2D Mouse mAb - Primary antibody, specific to NKG2D, Mouse IgG1

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Features and benefits

Short Overview:
mAb (1D11); Mouse anti Human NKG2D Antibody; Flow; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Mouse IgG1

Application:

Flow Cytometry

Item Number

Ab118154

Grouped product items
SKU	Size	Availability	Price
Ab118154-10μg	10μg	In stock	$26.90
Ab118154-50μg	50μg	In stock	$69.90
Ab118154-100μg	100μg	In stock	$109.90
Ab118154-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90

mAb (1D11); Mouse anti Human NKG2D Antibody; Flow; Unconjugated

View related series

Click to view target information: CASC3 Click to view target information: KLRK1

Accession#:P26718 Gene ID:22914 KLRK1 NKG2D

Basic Description

Product Name	NKG2D Mouse mAb - Primary antibody, specific to NKG2D, Mouse IgG1
Synonyms	CD314 antigen; CD314; D12S2489E; FLJ17759; FLJ75772; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; KLRK1; NK cell receptor D; NKG2-D type II integral membrane protein; NKG2D; NKG2-D; NK
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, Lot by Lot
Host species	Mouse
Specificity	NKG2D
Immunogen	NKL cells
Positive Control	Flow: Human peripheral blood lymphocytes.
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Validated
Product Description	Mouse anti Human NKG2D Antibody, Monoclonal (1D11), could be used for Flow and so on. Application: Flow: 1.0 μg/100w cells Protein Function Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.

Isotype

Mouse IgG1

Light Chain Type

kappa

SDS-PAGE

150 kDa

Purification Method

Protein G purified

Form

Liquid

Concentration

Lot by Lot

Storage Temp

Store at 2-8°C

Shipped In

Wet ice

Stability And Storage

Shipped at 4°C. Store at 4°C long term (12 months). Upon delivery aliquot.

Associated Targets(Human)

CASC3 Tbio Protein CASC3 (0 Activities)

Discover Target: CASC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLRK1 Tbio NKG2-D type II integral membrane protein (0 Activities)

Discover Target: KLRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Dilution info

Flow Cytometry

1μg/100w cells

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505808	Certificate of Analysis	May 20, 2024	Ab118154
ZJ24F0505807	Certificate of Analysis	May 20, 2024	Ab118154
ZJ24F0505806	Certificate of Analysis	May 20, 2024	Ab118154

References

1. Houchins JP, Yabe T, McSherry C, Bach FH. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.. J Exp Med, 173 (4): (1017-20). [PMID:2007850]
2. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T. () Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.. Science, [PMID:10426993]
3. Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T. () Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.. Nat Immunol, [PMID:11224526]
4. Glienke, J J and 7 more authors.. (1998) The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.. Immunogenetics, [PMID:9683661]
5. Wu, J J and 6 more authors.. (1999) An activating immunoreceptor complex formed by NKG2D and DAP10.. Science (New York, N.Y.), (30): [PMID:10426994]
6. Wu, J J, Cherwinski, H H, Spies, T T, Phillips, J H JH and Lanier, L L LL.. (2000) DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.. The Journal of experimental medicine, (2): [PMID:11015446]
7. Shum, Benny P BP and 8 more authors.. (2002) Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:11751968]
8. Radaev, S S, Rostro, B B, Brooks, A G AG, Colonna, M M and Sun, P D PD.. (2001) Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.. Immunity, [PMID:11754823]
9. Sutherland, Claire L CL and 5 more authors.. (2002) UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:11777960]
10. Vivier, Eric E, Tomasello, Elena E and Paul, Pascale P.. (2002) Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?. Current opinion in immunology, [PMID:11973127]
11. McFarland, Benjamin J BJ, Kortemme, Tanja T, Yu, Shuyuarn F SF, Baker, David D and Strong, Roland K RK.. (2003) Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands.. Structure (London, England : 1993), [PMID:12679019]
12. Bacon, Louise L and 5 more authors.. (2004) Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15240696]
13. Rosen, David B DB and 5 more authors.. (2004) A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15294961]
14. Chan, Camie W CW and 11 more authors.. (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.. Nature medicine, [PMID:16444266]
15. Scherer, Steven E SE and 216 more authors.. (2006) The finished DNA sequence of human chromosome 12.. Nature, (16): [PMID:16541075]
16. Eagle, Robert A RA, Traherne, James A JA, Hair, James R JR, Jafferji, Insiya I and Trowsdale, John J.. (2009) ULBP6/RAET1L is an additional human NKG2D ligand.. European journal of immunology, [PMID:19658097]
17. Zafirova, Biljana; Wensveen, Felix M; Gulin, Maja and Polić, Bojan.. (2011) Regulation of immune cell function and differentiation by the NKG2D receptor.. Cellular and molecular life sciences : CMLS, [PMID:21898152]
18. Raulet, David H DH, Gasser, Stephan S, Gowen, Benjamin G BG, Deng, Weiwen W and Jung, Heiyoun H.. (2013) Regulation of ligands for the NKG2D activating receptor.. Annual review of immunology, [PMID:23298206]
19. Hosomi, Shuhei S and 11 more authors.. (2013) CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.. European journal of immunology, [PMID:23696226]
20. Zuo, Jianmin J and 14 more authors.. (2017) A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.. Science signaling, (30): [PMID:28559451]

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