NLG919 - ≥98%, high purity , CAS No.1402836-58-1, Inhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of tryptophan 2;3-dioxygenase

Item Number
N129887
Grouped product items
SKUSizeAvailabilityPrice Qty
N129887-10mg
10mg
In stock
$37.90
N129887-50mg
50mg
In stock
$132.90
N129887-100mg
100mg
In stock
$211.90

Potent, small molecule IDO pathway inhibitor

Basic Description

SynonymsHY-13983 | BDBM50126144 | GTPL9019 | NLG919 (GDC-0919) | YTRRAUACYORZLX-UHFFFAOYSA-N | 2-Naphthalenesulfonic acid, 7, {7'-(carbonyldiimino)bis[4-hydroxy-3-(phenylazo)-,} | CCG-267268 | NCGC00386274-04 | SY046802 | SB16495 | 3-(2-Amino-ethyl)-5-[3-(4-butox
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsNLG919 is a potent indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (K i = 7 nM; EC 50 = 75 nM) in cell-free assays.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of tryptophan 2;3-dioxygenase
Product Description

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays.

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDO2 Tchem Tryptophan 2,3-dioxygenase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (18 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tdo2 Tryptophan 2,3-dioxygenase (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LLTC cell line (101 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ido1 Indoleamine 2,3-dioxygenase 1 (313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488202057
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202057
IUPAC Name 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
INCHI InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
InChi Key YTRRAUACYORZLX-UHFFFAOYSA-N
Canonical SMILES C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
Isomeric SMILES C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
PubChem CID 66558287
Molecular Weight 282.38

Certificates

Certificate of Analysis(COA)

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19 results found

Lot NumberCertificate TypeDateItem
L2215721Certificate of AnalysisSep 18, 2024 N129887
L2215719Certificate of AnalysisSep 18, 2024 N129887
G2226410Certificate of AnalysisMay 20, 2024 N129887
B2217040Certificate of AnalysisDec 19, 2023 N129887
J2326624Certificate of AnalysisOct 11, 2023 N129887
J2326643Certificate of AnalysisOct 11, 2023 N129887
H2307063Certificate of AnalysisJul 21, 2023 N129887
H2307075Certificate of AnalysisJul 21, 2023 N129887
H2307274Certificate of AnalysisJul 21, 2023 N129887
D2304206Certificate of AnalysisApr 08, 2023 N129887
D2328098Certificate of AnalysisApr 08, 2023 N129887
D2328109Certificate of AnalysisApr 08, 2023 N129887
D2328119Certificate of AnalysisApr 08, 2023 N129887
D2328120Certificate of AnalysisApr 08, 2023 N129887
L2215720Certificate of AnalysisAug 29, 2022 N129887
G2226428Certificate of AnalysisJun 14, 2022 N129887
G2226411Certificate of AnalysisJun 14, 2022 N129887
H1616020Certificate of AnalysisApr 25, 2022 N129887
B2217041Certificate of AnalysisJan 10, 2022 N129887

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Chemical and Physical Properties

SolubilityDMSO 56 mg/mL Water <1 mg/mL Ethanol 56 mg/mL

Related Documents

Citations of This Product

1. Hui Guo, Fangzhe Liu, Enqi Liu, Shanshan Wei, Wenbo Sun, Baoqiang Liu, Guoying Sun, Lehui Lu.  (2022)  Dual-responsive nano-prodrug micelles for MRI-guided tumor PDT and immune synergistic therapy.  Journal of Materials Chemistry B,  10  (22): (4261-4273).  [PMID:35583206] [10.1039/D1TB02790E]
2. Tiantian Zuo, Tianxu Fang, Jun Zhang, Jie Yang, Rui Xu, Zhihua Wang, Huizi Deng, Qi Shen.  (2021)  pH-Sensitive Molecular-Switch-Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy-Cascade Ferroptosis and Tumor Immune Activation.  Advanced Healthcare Materials,  10  (21): (2100683).  [PMID:34535975] [10.1002/adhm.202100683]
3. Liangliang Dai,Xiang Li,Mengjiao Yao,Peiyun Niu,Xichen Yuan,Ke Li,Maowen Chen,Zengxiang Fu,Xianglong Duan,Haibin Liu,Kaiyong Cai,Hui Yang.  (2020-02-29)  Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy..  Biomaterials,  241  (119901-119901).  [PMID:32109706]

References

1. Nayak-Kapoor A, Hao Z, Sadek R, Dobbins R, Marshall L, Vahanian NN, Jay Ramsey W, Kennedy E, Mautino MR, Link CJ et al..  (2018)  Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors..  J Immunother Cancer,  (1): (61).  [PMID:29921320] [10.1021/op500134e]
2. Ma S, Suchomel J, Yanez E, Yost E, Liang X, Zhu R, Le H, Siebers N, Joas L, Morley R et al..  (2019)  Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor..  Br J Clin Pharmacol,  85  (8): (1751-1760).  [PMID:30973970] [10.1021/op500134e]
3. Kumar S, Waldo JP, Jaipuri FA, Marcinowicz A, Van Allen C, Adams J, Kesharwani T, Zhang X, Metz R, Oh AJ et al..  (2019)  Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1..  J Med Chem,  62  (14): (6705-6733).  [PMID:31264862] [10.1021/op500134e]
4. Hui Guo, Fangzhe Liu, Enqi Liu, Shanshan Wei, Wenbo Sun, Baoqiang Liu, Guoying Sun, Lehui Lu.  (2022)  Dual-responsive nano-prodrug micelles for MRI-guided tumor PDT and immune synergistic therapy.  Journal of Materials Chemistry B,  10  (22): (4261-4273).  [PMID:35583206] [10.1039/D1TB02790E]
5. Tiantian Zuo, Tianxu Fang, Jun Zhang, Jie Yang, Rui Xu, Zhihua Wang, Huizi Deng, Qi Shen.  (2021)  pH-Sensitive Molecular-Switch-Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy-Cascade Ferroptosis and Tumor Immune Activation.  Advanced Healthcare Materials,  10  (21): (2100683).  [PMID:34535975] [10.1002/adhm.202100683]
6. Liangliang Dai,Xiang Li,Mengjiao Yao,Peiyun Niu,Xichen Yuan,Ke Li,Maowen Chen,Zengxiang Fu,Xianglong Duan,Haibin Liu,Kaiyong Cai,Hui Yang.  (2020-02-29)  Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy..  Biomaterials,  241  (119901-119901).  [PMID:32109706]

Solution Calculators