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NMDA - 100mmol/L in H2O, high purity , CAS No.6384-92-5
Excitotoxic amino acid. 1 ml water soluble pack.
Basic Description Synonyms NINDS_000392 | CHEBI:31882 | (R)-2-(Methylamino)succinic acid hydrochloride | KBio2_007072 | NCGC00015666-01 | (2R)-2-(methylamino)butanedioic acid | SR-01000597701-1 | Tox21_500775 | (R)-2-Ethylbutannedioic acid | UNII-1903B9Q6PI | (R)-2-(Methylamino)suc Specifications & Purity Moligand™, 100mmol/L in H2O Biochemical and Physiological Mechanisms Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy. Soluble in 1 ml water to give specified mM/ml concentration. Find out more. Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™ Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Melagatran, the active molecule, binds to the arginine side pocket of thrombin. Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens Exosite I region Thrombin inhibitor INHIBITOR ALA204 Thrombin SINGLE PROTEIN Homo sapiens
Names and Identifiers IUPAC Name (2R)-2-(methylamino)butanedioic acid INCHI InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 InChi Key HOKKHZGPKSLGJE-GSVOUGTGSA-N Canonical SMILES CNC(CC(=O)O)C(=O)O Isomeric SMILES CN[C@H](CC(=O)O)C(=O)O RTECS CI9457000 PubChem CID 22880 Molecular Weight 147.13 Beilstein 1724431 Reaxy-Rn 1724431
Certificates(CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble in 1ml of water to give specified mM/ml concentration Specific Rotation[α] -15° (C=2,H2O) Melt Point(°C) 178 °C
Safety and Hazards(GHS) RTECS CI9457000 Reaxy-Rn 1724431 Merck Index 6662
Citations of This Product (3 ) 1. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi. (2023) Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 262 (115344). [PMID:37567108 ] [10.1016/j.ecoenv.2023.115344 ] 2. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang. (2023) Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, [PMID:36591642 ] [10.1080/07391102.2022.2159527 ] 3. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang. (2022) Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume. FITOTERAPIA, 163 (105338). [PMID:36270560 ] [10.1016/j.fitote.2022.105338 ]
References 1. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi. (2023) Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 262 (115344). [PMID:37567108 ] [10.1016/j.ecoenv.2023.115344 ] 2. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang. (2023) Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, [PMID:36591642 ] [10.1080/07391102.2022.2159527 ] 3. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang. (2022) Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume. FITOTERAPIA, 163 (105338). [PMID:36270560 ] [10.1016/j.fitote.2022.105338 ]
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