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NNC 0640 - ≥97%(HPLC), high purity , CAS No.307986-98-7, Allosteric modulator of glucagon receptor
Negative allosteric modulator of Glukagon and GLP-1 receptors
Basic Description Specifications & Purity Moligand™, ≥97%(HPLC) Biochemical and Physiological Mechanisms Negative allosteric modulator of Glukagon receptors (pKi= 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of Glukagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulationin vitro. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of glucagon receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-[[4-cyclohexyl-N-[(3-methylsulfonylphenyl)carbamoyl]anilino]methyl]-N-(2H-tetrazol-5-yl)benzamide INCHI InChI=1S/C29H31N7O4S/c1-41(39,40)26-9-5-8-24(18-26)30-29(38)36(25-16-14-22(15-17-25)21-6-3-2-4-7-21)19-20-10-12-23(13-11-20)27(37)31-28-32-34-35-33-28/h5,8-18,21H,2-4,6-7,19H2,1H3,(H,30,38)(H2,31,32,33,34,35,37) InChi Key PPTKULJUDJWTSA-UHFFFAOYSA-N Canonical SMILES CS(=O)(=O)C1=CC=CC(=C1)NC(=O)N(CC2=CC=C(C=C2)C(=O)NC3=NNN=N3)C4=CC=C(C=C4)C5CCCCC5 Isomeric SMILES CS(=O)(=O)C1=CC=CC(=C1)NC(=O)N(CC2=CC=C(C=C2)C(=O)NC3=NNN=N3)C4=CC=C(C=C4)C5CCCCC5 PubChem CID 23549991 UN Number 1325 Packing Group II MeSH Entry Terms 4-(1-(4-cyclohexylphenyl)-3-(3-methanesulfonylphenyl)ureidomethyl)-N-(2H-tetrazol-5-yl)benzamide;NNC0640 Molecular Weight 573.67
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 57.37, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 , GHS02 Signal Danger Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H302: Harmful if swallowed
H228: Flammable solid
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P210: Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.
P302+P352: IF ON SKIN: wash with plenty of water.
P240: Ground/bond container and receiving equipment.
P264: Wash hands [and …] thoroughly after handling.
P241: Use explosion-proof [electrical/ventilating/lighting/.../] equipment.
P337+P313: IF eye irritation persists: Get medical advice/attention.
P332+P313: IF SKIN irritation occurs: Get medical advice/attention.
Class 4.1
References 1. Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW et al. . (2017) Structure of the full-length glucagon class B G-protein-coupled receptor.. Nature, 546 (7657): (259-264). [PMID:28514451 ] [10.1021/op500134e ]
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H2213260