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SKU | Size | Availability | Price | Qty |
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N274674-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $201.90 | |
N274674-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $846.90 |
Potent, selective GAT-1 inhibitor
Synonyms | 145645-62-1 | NO-711 hydrochloride | NNC 711 | NNC-711 (hydrochloride) | NO-711 HCl | 1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid | NNC711 | 1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC A |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Potent and selective GAT-1 GABA uptake inhibitor. (IC 50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro . Potent a |
Storage Temp | Store at 2-8°C,Desiccated |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | 1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydrochloride |
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INCHI | InChI=1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H |
InChi Key | YZYRTEYMUTWJPL-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl |
Isomeric SMILES | C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl |
PubChem CID | 123738 |
Molecular Weight | 386.87 |
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Solubility | Soluble in water to 10 mM |
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1. Romo-Parra H et al.. (2015) Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice.. J Neurophysiol, 113 (9): (3421-31). [PMID:25787948] |