Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N275540-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
N275540-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $139.90 | |
N275540-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $239.90 | |
N275540-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $489.90 | |
N275540-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $799.90 |
Broad spectrum MMP inhibitor
Synonyms | N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide | AKOS040744915 | 9P3H27MP46 | mmp-3 inhibitor ii | 2-((4-Methoxyphenyl)sulfonyl-(2-methylpropyl)amino)-N-oxidanyl-ethanamide | CS-0077845 | N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]-N~ |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | MMP3 (Stromelysin-1) inhibitor. Additionally shows broad spectrum inhibition activity at other MMPs. Cell permeable. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description |
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression
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IUPAC Name | N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide |
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INCHI | InChI=1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16) |
InChi Key | JIRXORZYIXSWOB-UHFFFAOYSA-N |
Canonical SMILES | CC(C)CN(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OC |
Isomeric SMILES | CC(C)CN(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OC |
PubChem CID | 448002 |
Molecular Weight | 316.37 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2419527 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419528 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419529 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419530 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419531 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419536 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419537 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419538 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419545 | Certificate of Analysis | Aug 02, 2024 | N275540 |
H2419546 | Certificate of Analysis | Aug 02, 2024 | N275540 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 25 mM |
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Sensitivity | Moisture sensitive. |
1. Liang M et al.. (2021) Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy.. Transl Oncol, 14 (12): (101221). [PMID:34530193] |