Nω-Nitro-L-arginine - 98%, high purity , CAS No.2149-70-4, Inhibitor of Endothelial NOS;Inhibitor of Inducible NOS;Inhibitor of Neuronal NOS

Item Number

N109208

• Synonyms: NCGC00024716-09 | Spectrum3_001083 | Arginine, omega-nitro-, L- | KBio1_001016 | Q7041453 | SR-01000597670 | N(sup G)-Nitro-L-arginine | N-Nitro-L-arginine | (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid | EN300-204408 | hDDAH inhibito
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Nitric oxide synthase inhibitor (K i = 4.4 μM). Cardiovascular effects. Active in vivo .
• Shipped In: Normal
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of Endothelial NOS;Inhibitor of Inducible NOS;Inhibitor of Neuronal NOS
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Nω-Nitro-L-arginine displays potent inhibition of NOS with selectivity for NOS1 and NOS3 over NOS2. It has been observed to inhibit endothelial nitric oxide biosynthesis and decrease radical generation of peroxynitrite ions. Other inhibitory effects demonstrated in experiments include blocking brady-kinin-induced relaxation in dog coronary artery strips and suppressing morphine tolerance in mice. N G-Nitro-L-arginine causes significant vasoconstriction and is utilized in studying nitric oxide as a neuronal messenger.

Application

Nω-Nitro-L-arginine has been used:as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay to pretreat fiber bundles for contractile studies；as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells；as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations.