Nω-Nitro-L-arginine methyl ester hydrochloride - 98%, high purity , CAS No.51298-62-5

  • ≥98%
Item Number
N109211
Grouped product items
SKUSizeAvailabilityPrice Qty
N109211-250mg
250mg
In stock
$9.90
N109211-1g
1g
In stock
$19.90
N109211-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$67.90
N109211-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$107.90
N109211-25g
25g
In stock
$215.90
N109211-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$604.90

NOS inhibitor

Basic Description

SynonymsDTXSID10199292 | N(gamma)-nitro-L-arginine methyl ester monohydrochloride | QBNXAGZYLSRPJK-JEDNCBNOSA-N | H-Arg(NO)-OMe HCl | MLS001056504 | AS-17653 | CCRIS 6739 | HY-18729A | Tox21_500848 | Methyl Nw-nitro-L-argininate hydrochloride | H-Arg(NO2)-OMe.HCl
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAn analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodil
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:

• to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons

• to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin

• to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells

• to study its effect on the levels of arginine Vasotocin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat


Associated Targets(Human)

NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATM Tchem Serine-protein kinase ATM (4198 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS1 Tchem Nitric oxide sythases; iNOS & nNOS (685 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488187832
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187832
IUPAC Name methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate;hydrochloride
INCHI InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChi Key QBNXAGZYLSRPJK-JEDNCBNOSA-N
Canonical SMILES COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl
Isomeric SMILES COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl
WGK Germany 3
PubChem CID 135193
Molecular Weight 269.69
Beilstein 3744166
Reaxy-Rn 3744166

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot NumberCertificate TypeDateItem
L2411581Certificate of AnalysisSep 24, 2024 N109211
L2411578Certificate of AnalysisSep 24, 2024 N109211
L2411577Certificate of AnalysisSep 24, 2024 N109211
L2411573Certificate of AnalysisSep 24, 2024 N109211
L1221015Certificate of AnalysisAug 12, 2024 N109211
D2402359Certificate of AnalysisMar 21, 2024 N109211
D2402361Certificate of AnalysisMar 21, 2024 N109211
D2402360Certificate of AnalysisMar 21, 2024 N109211
D2402358Certificate of AnalysisMar 21, 2024 N109211
D2402357Certificate of AnalysisMar 21, 2024 N109211
B2311688Certificate of AnalysisJan 06, 2023 N109211
B2311843Certificate of AnalysisJan 06, 2023 N109211
B2311842Certificate of AnalysisJan 06, 2023 N109211
G2305132Certificate of AnalysisJan 06, 2023 N109211
B2311841Certificate of AnalysisJan 06, 2023 N109211
B2311812Certificate of AnalysisJan 06, 2023 N109211
B2311811Certificate of AnalysisJan 06, 2023 N109211
B2311794Certificate of AnalysisJan 06, 2023 N109211
B2311724Certificate of AnalysisJan 06, 2023 N109211
J1829026Certificate of AnalysisAug 15, 2022 N109211
J1829025Certificate of AnalysisAug 15, 2022 N109211

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Chemical and Physical Properties

Specific Rotation[α]15 ° (C=3, MeOH)
Melt Point(°C)159-161°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 3744166

Related Documents

Citations of This Product

1. Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Meng.  (2023)  Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis..  BEHAVIOURAL BRAIN RESEARCH,    (114627).  [PMID:37619770] [10.1016/j.bbr.2023.114627]
2. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du.  (2023)  An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO.  CHEMICAL ENGINEERING JOURNAL,  471  (144797).  [PMID:] [10.1016/j.cej.2023.144797]
3. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong.  (2023)  Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.  MOLECULAR BIOTECHNOLOGY,    (1-13).  [PMID:37277581] [10.1007/s12033-023-00774-3]
4. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping.  (2022)  Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production.  JOURNAL OF APPLIED MICROBIOLOGY,  132  (2): (1370-1383).  [PMID:34470077] [10.1111/jam.15279]
5. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han.  (2022)  Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses.  CHEMICAL RESEARCH IN TOXICOLOGY,  35  (2): (244–253).  [PMID:35081708] [10.1021/acs.chemrestox.1c00299]
6. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge.  (2020)  A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats.  Frontiers in Pharmacology,  11    [PMID:33329004] [10.3389/fphar.2020.599577]
7. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng.  (2016)  Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.  PLoS One,  11  (2): (e0149032).  [PMID:26866373] [10.1371/journal.pone.0149032]

References

1. Ren H et al..  (2019)  Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide..  Arch Oral Biol,  101  (108-121).  [PMID:30927660]
2. Barbaro NR et al..  (2017)  Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension..  Cell Rep,  21  (4): (1009-1020).  [PMID:29069584]
3. Aboouf MA et al..  (2022)  Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT..  Front Oncol,  12  (976961).  [PMID:36052260]
4. Marangoni A et al..  (2014)  Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study..  BMC Res Notes,  (230).  [PMID:24721461]
5. Tabansky I et al..  (2018)  Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal..  Proc Natl Acad Sci U S A,  115  (29): (E6900-E6909).  [PMID:29967172]
6. Foster JD et al..  (2014)  Nitric oxide-mediated modulation of the murine locomotor network..  J Neurophysiol,  111  (3): (659-74).  [PMID:24259545]
7. Liu W et al..  (2020)  Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex..  Front Psychiatry,  11  (837).  [PMID:33088274]
8. Pal S et al..  (2020)  Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs..  Bone,  135  (115305).  [PMID:32126313]
9. Belvedere R et al..  (2017)  The Pharmaceutical Device Prisma®Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing..  Int J Mol Sci,  18  (8):   [PMID:28757565]
10. Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Meng.  (2023)  Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis..  BEHAVIOURAL BRAIN RESEARCH,    (114627).  [PMID:37619770] [10.1016/j.bbr.2023.114627]
11. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du.  (2023)  An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO.  CHEMICAL ENGINEERING JOURNAL,  471  (144797).  [PMID:] [10.1016/j.cej.2023.144797]
12. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong.  (2023)  Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.  MOLECULAR BIOTECHNOLOGY,    (1-13).  [PMID:37277581] [10.1007/s12033-023-00774-3]
13. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping.  (2022)  Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production.  JOURNAL OF APPLIED MICROBIOLOGY,  132  (2): (1370-1383).  [PMID:34470077] [10.1111/jam.15279]
14. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han.  (2022)  Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses.  CHEMICAL RESEARCH IN TOXICOLOGY,  35  (2): (244–253).  [PMID:35081708] [10.1021/acs.chemrestox.1c00299]
15. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge.  (2020)  A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats.  Frontiers in Pharmacology,  11    [PMID:33329004] [10.3389/fphar.2020.599577]
16. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng.  (2016)  Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.  PLoS One,  11  (2): (e0149032).  [PMID:26866373] [10.1371/journal.pone.0149032]

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