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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N109211-250mg | 250mg | In stock | $9.90 | |
N109211-1g | 1g | In stock | $19.90 | |
N109211-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $67.90 | |
N109211-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $107.90 | |
N109211-25g | 25g | In stock | $215.90 | |
N109211-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $604.90 |
NOS inhibitor
Synonyms | DTXSID10199292 | N(gamma)-nitro-L-arginine methyl ester monohydrochloride | QBNXAGZYLSRPJK-JEDNCBNOSA-N | H-Arg(NO)-OMe HCl | MLS001056504 | AS-17653 | CCRIS 6739 | HY-18729A | Tox21_500848 | Methyl Nw-nitro-L-argininate hydrochloride | H-Arg(NO2)-OMe.HCl |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodil |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Nω-Nitro-L-arginine methyl ester hydrochloride has been used: • to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons • to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin • to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells • to study its effect on the levels of arginine Vasotocin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488187832 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187832 |
IUPAC Name | methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate;hydrochloride |
INCHI | InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1 |
InChi Key | QBNXAGZYLSRPJK-JEDNCBNOSA-N |
Canonical SMILES | COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl |
Isomeric SMILES | COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl |
WGK Germany | 3 |
PubChem CID | 135193 |
Molecular Weight | 269.69 |
Beilstein | 3744166 |
Reaxy-Rn | 3744166 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2411581 | Certificate of Analysis | Sep 24, 2024 | N109211 |
L2411578 | Certificate of Analysis | Sep 24, 2024 | N109211 |
L2411577 | Certificate of Analysis | Sep 24, 2024 | N109211 |
L2411573 | Certificate of Analysis | Sep 24, 2024 | N109211 |
L1221015 | Certificate of Analysis | Aug 12, 2024 | N109211 |
D2402359 | Certificate of Analysis | Mar 21, 2024 | N109211 |
D2402361 | Certificate of Analysis | Mar 21, 2024 | N109211 |
D2402360 | Certificate of Analysis | Mar 21, 2024 | N109211 |
D2402358 | Certificate of Analysis | Mar 21, 2024 | N109211 |
D2402357 | Certificate of Analysis | Mar 21, 2024 | N109211 |
B2311688 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311843 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311842 | Certificate of Analysis | Jan 06, 2023 | N109211 |
G2305132 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311841 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311812 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311811 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311794 | Certificate of Analysis | Jan 06, 2023 | N109211 |
B2311724 | Certificate of Analysis | Jan 06, 2023 | N109211 |
J1829026 | Certificate of Analysis | Aug 15, 2022 | N109211 |
J1829025 | Certificate of Analysis | Aug 15, 2022 | N109211 |
Specific Rotation[α] | 15 ° (C=3, MeOH) |
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Melt Point(°C) | 159-161°C |
WGK Germany | 3 |
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Reaxy-Rn | 3744166 |
Starting at $50.90
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2. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du. (2023) An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO. CHEMICAL ENGINEERING JOURNAL, 471 (144797). [PMID:] [10.1016/j.cej.2023.144797] |
3. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong. (2023) Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia. MOLECULAR BIOTECHNOLOGY, (1-13). [PMID:37277581] [10.1007/s12033-023-00774-3] |
4. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping. (2022) Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production. JOURNAL OF APPLIED MICROBIOLOGY, 132 (2): (1370-1383). [PMID:34470077] [10.1111/jam.15279] |
5. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han. (2022) Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses. CHEMICAL RESEARCH IN TOXICOLOGY, 35 (2): (244–253). [PMID:35081708] [10.1021/acs.chemrestox.1c00299] |
6. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge. (2020) A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats. Frontiers in Pharmacology, 11 [PMID:33329004] [10.3389/fphar.2020.599577] |
7. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng. (2016) Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways. PLoS One, 11 (2): (e0149032). [PMID:26866373] [10.1371/journal.pone.0149032] |
1. Ren H et al.. (2019) Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide.. Arch Oral Biol, 101 (108-121). [PMID:30927660] |
2. Barbaro NR et al.. (2017) Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.. Cell Rep, 21 (4): (1009-1020). [PMID:29069584] |
3. Aboouf MA et al.. (2022) Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT.. Front Oncol, 12 (976961). [PMID:36052260] |
4. Marangoni A et al.. (2014) Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study.. BMC Res Notes, 7 (230). [PMID:24721461] |
5. Tabansky I et al.. (2018) Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.. Proc Natl Acad Sci U S A, 115 (29): (E6900-E6909). [PMID:29967172] |
6. Foster JD et al.. (2014) Nitric oxide-mediated modulation of the murine locomotor network.. J Neurophysiol, 111 (3): (659-74). [PMID:24259545] |
7. Liu W et al.. (2020) Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex.. Front Psychiatry, 11 (837). [PMID:33088274] |
8. Pal S et al.. (2020) Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.. Bone, 135 (115305). [PMID:32126313] |
9. Belvedere R et al.. (2017) The Pharmaceutical Device Prisma®Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing.. Int J Mol Sci, 18 (8): [PMID:28757565] |
10. Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Meng. (2023) Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis.. BEHAVIOURAL BRAIN RESEARCH, (114627). [PMID:37619770] [10.1016/j.bbr.2023.114627] |
11. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du. (2023) An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO. CHEMICAL ENGINEERING JOURNAL, 471 (144797). [PMID:] [10.1016/j.cej.2023.144797] |
12. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong. (2023) Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia. MOLECULAR BIOTECHNOLOGY, (1-13). [PMID:37277581] [10.1007/s12033-023-00774-3] |
13. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping. (2022) Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production. JOURNAL OF APPLIED MICROBIOLOGY, 132 (2): (1370-1383). [PMID:34470077] [10.1111/jam.15279] |
14. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han. (2022) Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses. CHEMICAL RESEARCH IN TOXICOLOGY, 35 (2): (244–253). [PMID:35081708] [10.1021/acs.chemrestox.1c00299] |
15. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge. (2020) A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats. Frontiers in Pharmacology, 11 [PMID:33329004] [10.3389/fphar.2020.599577] |
16. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng. (2016) Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways. PLoS One, 11 (2): (e0149032). [PMID:26866373] [10.1371/journal.pone.0149032] |