An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodil
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
• to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
• to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
• to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
• to study its effect on the levels of arginine Vasotocin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat
1.Ren H et al.. (2019) Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide.. Arch Oral Biol, 101 (108-121). [PMID:30927660]
2.Barbaro NR et al.. (2017) Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.. Cell Rep, 21 (4):(1009-1020). [PMID:29069584]
3.Aboouf MA et al.. (2022) Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT.. Front Oncol, 12 (976961). [PMID:36052260]
4.Marangoni A et al.. (2014) Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study.. BMC Res Notes, 7 (230). [PMID:24721461]
5.Tabansky I et al.. (2018) Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.. Proc Natl Acad Sci U S A, 115 (29):(E6900-E6909). [PMID:29967172]
6.Foster JD et al.. (2014) Nitric oxide-mediated modulation of the murine locomotor network.. J Neurophysiol, 111 (3):(659-74). [PMID:24259545]
7.Liu W et al.. (2020) Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex.. Front Psychiatry, 11 (837). [PMID:33088274]
8.Pal S et al.. (2020) Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.. Bone, 135 (115305). [PMID:32126313]
9.Belvedere R et al.. (2017) The Pharmaceutical Device Prisma®Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing.. Int J Mol Sci, 18 (8):[PMID:28757565]
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L1221015