Nω-Nitro-L-arginine methyl ester hydrochloride - 10mM in Water, high purity , CAS No.51298-62-5

  • 10mM in Water
Item Number
N424409
Grouped product items
SKUSizeAvailabilityPrice Qty
N424409-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$50.90

NOS inhibitor

Basic Description

Synonyms51298-62-5 | L-NAME hydrochloride | H-Arg(NO2)-OMe.HCl | LNAME hydrochloride | H-Arg(NO2)-Ome HCl | L-NAME HCl | Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride | NG-Nitro-L-arginine methyl ester hydrochloride | L-NAME (hydrochloride) | (S)-Methyl 2-amino
Specifications & Purity10mM in Water
Biochemical and Physiological MechanismsAn analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodil
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:

• to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons

• to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin

• to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells

• to study its effect on the levels of arginine Vasotocin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat


Associated Targets(Human)

GMNN Tbio Geminin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KAT2A Tchem Histone acetyltransferase KAT2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLI Tchem DNA polymerase iota (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ATM Tchem Serine-protein kinase ATM (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS2 Tchem Nitric oxide synthase, inducible (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS1 Tchem Nitric oxide synthase, brain (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS3 Tchem Nitric oxide synthase, endothelial (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATM Tchem Serine-protein kinase ATM (4198 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS1 Tchem Nitric oxide sythases; iNOS & nNOS (685 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate;hydrochloride
INCHI InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChi Key QBNXAGZYLSRPJK-JEDNCBNOSA-N
Canonical SMILES COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl
Isomeric SMILES COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl
WGK Germany 3
PubChem CID 135193
Molecular Weight 269.69
Beilstein 3744166
Reaxy-Rn 3744166

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Specific Rotation[α]15 ° (C=3, MeOH)
Melt Point(°C)159-161°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 3744166

Related Documents

Citations of This Product

1. Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Meng.  (2023)  Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis..  BEHAVIOURAL BRAIN RESEARCH,    (114627).  [PMID:37619770] [10.1016/j.bbr.2023.114627]
2. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du.  (2023)  An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO.  CHEMICAL ENGINEERING JOURNAL,  471  (144797).  [PMID:] [10.1016/j.cej.2023.144797]
3. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong.  (2023)  Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.  MOLECULAR BIOTECHNOLOGY,    (1-13).  [PMID:37277581] [10.1007/s12033-023-00774-3]
4. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping.  (2022)  Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production.  JOURNAL OF APPLIED MICROBIOLOGY,  132  (2): (1370-1383).  [PMID:34470077] [10.1111/jam.15279]
5. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han.  (2022)  Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses.  CHEMICAL RESEARCH IN TOXICOLOGY,  35  (2): (244–253).  [PMID:35081708] [10.1021/acs.chemrestox.1c00299]
6. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge.  (2020)  A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats.  Frontiers in Pharmacology,  11    [PMID:33329004] [10.3389/fphar.2020.599577]
7. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng.  (2016)  Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.  PLoS One,  11  (2): (e0149032).  [PMID:26866373] [10.1371/journal.pone.0149032]

References

1. Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Meng.  (2023)  Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis..  BEHAVIOURAL BRAIN RESEARCH,    (114627).  [PMID:37619770] [10.1016/j.bbr.2023.114627]
2. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du.  (2023)  An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO.  CHEMICAL ENGINEERING JOURNAL,  471  (144797).  [PMID:] [10.1016/j.cej.2023.144797]
3. Chang Ruijing, Su Yuan, Kong Hongfang, Wang Fang, Xing Ying, Jiang Lei, Xin Hong.  (2023)  Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.  MOLECULAR BIOTECHNOLOGY,    (1-13).  [PMID:37277581] [10.1007/s12033-023-00774-3]
4. Yong Wenjing, Zhao Yanhua, Jiang Xiao’e, Li Ping.  (2022)  Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production.  JOURNAL OF APPLIED MICROBIOLOGY,  132  (2): (1370-1383).  [PMID:34470077] [10.1111/jam.15279]
5. Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han.  (2022)  Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses.  CHEMICAL RESEARCH IN TOXICOLOGY,  35  (2): (244–253).  [PMID:35081708] [10.1021/acs.chemrestox.1c00299]
6. Huang Shuo, Tang Yanyan, Liu Tianjun, Zhang Ning, Yang Xueyan, Yang Dingwei, Hong Ge.  (2020)  A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats.  Frontiers in Pharmacology,  11    [PMID:33329004] [10.3389/fphar.2020.599577]
7. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng.  (2016)  Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.  PLoS One,  11  (2): (e0149032).  [PMID:26866373] [10.1371/journal.pone.0149032]

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