Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N129755-10mg | 10mg | In stock | $64.90 | |
N129755-50mg | 50mg | In stock | $224.90 | |
N129755-250mg | 250mg | In stock | $1,012.90 |
Microtubule inhibitor
Synonyms | HMS587E01 | Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate | MLS001164242 | DTXCID7011800 | KBio3_002735 | Prestwick2_000100 | Tocris-1228 | Bio1_000950 | cid_4122 | Methyl(5-(2-thienylcarbonyl))-1H-benzimidazole-2-yl carbamate | Nocodazol |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.Microtubule inhibitor. Rapidly depolymerises microtubules in vivo and inhibits |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Nocodazole is a reversible anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules (tubulin). Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. Nocodazole is frequently employed in cell biology laboratories to synchronize the cell division cycle; cells treated with nocodazole arrest with a G2- or M-phase DNA content when analyzed by flow cytometry. Nocodazole has also been used to induce the formation of Golgi ministacks in eukaryotic cells due to lack of proper Tubulin function. |
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IUPAC Name | methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate |
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INCHI | InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19) |
InChi Key | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
Canonical SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3 |
Isomeric SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3 |
WGK Germany | 3 |
RTECS | DD6521000 |
PubChem CID | 4122 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 301.32 |
Beilstein | 1085978 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2206883 | Certificate of Analysis | Oct 09, 2023 | N129755 |
A2206884 | Certificate of Analysis | Oct 09, 2023 | N129755 |
C2405080 | Certificate of Analysis | Oct 09, 2023 | N129755 |
K2009155 | Certificate of Analysis | Sep 15, 2022 | N129755 |
H2304186 | Certificate of Analysis | Dec 08, 2021 | N129755 |
K2216301 | Certificate of Analysis | Dec 08, 2021 | N129755 |
Solubility | Soluble in DMSO (10 mg/ml);Soluble in Ethanol (1 mg/ml) |
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Sensitivity | Heat sensitive |
Melt Point(°C) | 260 °C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H341:Suspected of causing genetic defects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P281:Use personal protective equipment as required. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | DD6521000 |
Class | 6.1 |
1. Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao, Haifang Wang. (2023) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials, 13 (1): (84). [PMID:36615994] |
2. Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2022) Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (24): (15607). [PMID:36555247] |
3. Siqin Chen, Quan Zhou, Guowei Wang, Zhuxian Zhou, Jianbin Tang, Tao Xie, Youqing Shen. (2021) Effect of Cationic Charge Density on Transcytosis of Polyethylenimine. BIOMACROMOLECULES, 22 (12): (5139–5150). [PMID:34775750] |
4. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang. (2021) Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis. Advanced Healthcare Materials, 11 (2): (2101926). [PMID:34738742] |
1. Lee BY & Hur EM. (2020) A Role of Microtubules in Oligodendrocyte Differentiation.. Int J Mol Sci, 21 (3): [PMID:32033476] |
2. Tabdanov ED et al.. (2018) Bimodal sensing of guidance cues in mechanically distinct microenvironments.. Nat Commun, 9 (4891). [PMID:30459308] |
3. Salemi LM et al.. (2015) Characterization of RanBPM molecular determinants that control its subcellular localization.. PLoS One, 10 (2): (e0117655). [PMID:25659156] |
4. Yan H et al.. (2022) CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.. Cell Prolif, 55 (5): (e13240). [PMID:35509151] |
5. Ocampo J et al.. (2019) Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination.. Genome Res, 29 (3): (407-417). [PMID:30683752] |
6. Endo Y et al.. (2022) Genome‑wide DNA hypomethylation drives a more invasive pancreatic cancer phenotype and has predictive occult distant metastasis and prognosis potential.. Int J Oncol, 60 (6): [PMID:35419613] |
7. Vasquez RJ et al.. (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.. Mol Biol Cell, 8 (6): (973-85). [PMID:9201709] |
8. Ramos D et al.. (2016) Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells.. PLoS One, 11 (3): (e0149516). [PMID:26934375] |
9. Musa H et al.. (2003) Microtubule assembly in cultured myoblasts and myotubes following nocodazole induced microtubule depolymerisation.. J Muscle Res Cell Motil, 24 (4-6): (301-8). [PMID:14620743] |
10. Tabdanov ED et al.. (2018) Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.. Cell Rep, 25 (2): (328-338.e5). [PMID:30304674] |
11. Kallas A et al.. (2011) Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells.. PLoS One, 6 (4): (e19114). [PMID:21559451] |
12. Wu B et al.. (2020) Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.. Cell Metab, 32 (6): (967-980.e5). [PMID:33264602] |
13. Sugita S et al.. (2019) Tumor-suppressive microRNA-223 targets WDR62 directly in bladder cancer.. Int J Oncol, 54 (6): (2222-2236). [PMID:30942440] |
14. Wufa Fan,§ Jiajia Xiang,§ Qiuyu Wei,§ Yisi Tang,§ Ying Piao, Shiqun Shao, Zhuxian Zhou,* Jianbin Tang, Zi-Chen Li,* and Youqing Shen*. (2023) Role of Micelle Size in Cell Transcytosis-Based Tumor Extravasation, Infiltration, and Treatment Efficacy. Nano letters, 9 (23): (3904-3912). [PMID:37043295] |
15. Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao, Haifang Wang. (2023) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials, 13 (1): (84). [PMID:36615994] |
16. Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2022) Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (24): (15607). [PMID:36555247] |
17. Siqin Chen, Quan Zhou, Guowei Wang, Zhuxian Zhou, Jianbin Tang, Tao Xie, Youqing Shen. (2021) Effect of Cationic Charge Density on Transcytosis of Polyethylenimine. BIOMACROMOLECULES, 22 (12): (5139–5150). [PMID:34775750] |
18. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang. (2021) Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis. Advanced Healthcare Materials, 11 (2): (2101926). [PMID:34738742] |