(+)-nootkatone, a bicyclic conjugated sesquiterpene ketone with a grapefruit-like flavor, is commonly used in fragrance, food, cosmetics and pharmaceutical industry. It can be synthesized from (+)-valencene via biotransformation. (+)-nootkatone is the active ingredient responsible for the antiplatelet effect of Cyperus rotundus, a well-known oriental traditional medicine.
1.Chongshan Dai, Xueyong Zhang, Jiahao Lin, Jianzhong Shen. (2023) Nootkatone Supplementation Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury via the Inhibition of Oxidative Stress, NF-κB Pathways, and the Activation of Nrf2/HO-1 Pathway. Antioxidants, 12 (1):(194). [PMID:36671056][10.3390/antiox12010194]
2.Ruige Yang, Meiyue Han, Jiangping Fan, Wanqing Cheng, Nannan Ma, Xiaoting Yan, Yong Guo. (2021) Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (51):(15544–15553). [PMID:34919380][10.1021/acs.jafc.1c05853]
3.Yong Guo, Enhua Hou, Nannan Ma, Zhiyan Liu, Jiangping Fan, Ruige Yang. (2020) Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors. BIOORGANIC CHEMISTRY, 104 (104294). [PMID:32987307][10.1016/j.bioorg.2020.104294]
4.Yong Guo, Zhiyan Liu, Enhua Hou, Nannan Ma, Jiangping Fan, Cheng-Yun Jin, Ruige Yang. (2020) Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach. INDUSTRIAL CROPS AND PRODUCTS, 156 (112864). [PMID:][10.1016/j.indcrop.2020.112864]
References
1.Chongshan Dai, Xueyong Zhang, Jiahao Lin, Jianzhong Shen. (2023) Nootkatone Supplementation Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury via the Inhibition of Oxidative Stress, NF-κB Pathways, and the Activation of Nrf2/HO-1 Pathway. Antioxidants, 12 (1):(194). [PMID:36671056][10.3390/antiox12010194]
2.Ruige Yang, Meiyue Han, Jiangping Fan, Wanqing Cheng, Nannan Ma, Xiaoting Yan, Yong Guo. (2021) Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (51):(15544–15553). [PMID:34919380][10.1021/acs.jafc.1c05853]
3.Yong Guo, Enhua Hou, Nannan Ma, Zhiyan Liu, Jiangping Fan, Ruige Yang. (2020) Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors. BIOORGANIC CHEMISTRY, 104 (104294). [PMID:32987307][10.1016/j.bioorg.2020.104294]
4.Yong Guo, Zhiyan Liu, Enhua Hou, Nannan Ma, Jiangping Fan, Cheng-Yun Jin, Ruige Yang. (2020) Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach. INDUSTRIAL CROPS AND PRODUCTS, 156 (112864). [PMID:][10.1016/j.indcrop.2020.112864]
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