noradrenaline , CAS No.138-65-8, Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of D 1 receptor;Agonist of D 5 receptor

Item Number
N612358
Grouped product items
SKUSizeAvailabilityPrice Qty
N612358-25μg
25μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N612358-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,334.90

Basic Description

SynonymsNCGC00185992-01 | (.+/-.)-Arterenol | HR-0338 | AC-10030 | EINECS 205-337-9 | Noradrop | NSC294898 | NSC-294898 | 4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol | 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol | CHEBI:33569 | CCG-204148 | DL-[7-3H]norepinephrine
Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of D 1 receptor;Agonist of D 5 receptor

Associated Targets(Human)

DRD1 Tclin D(1A) dopamine receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD5 Tchem D(1B) dopamine receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB1 Tclin Beta-1 adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Taar1 Trace amine-associated receptor 1 (899 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phosphoglycerate kinase, glycosomal (2184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra1b Adrenergic receptor alpha (950 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol
INCHI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
InChi Key SFLSHLFXELFNJZ-UHFFFAOYSA-N
Canonical SMILES NCC(c1ccc(c(c1)O)O)O
Isomeric SMILES C1=CC(=C(C=C1C(CN)O)O)O
PubChem CID 951

Certificates

Certificate of Analysis(COA)

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Related Documents

Citations of This Product

1. Lin Liu, Guifang Wang, Qingqin Feng, Yun Xing, Hongxing Han, Min Jing.  (2013)  Specific and Amplified Voltammetric Detection of Dopamine at Nitrilotriacetic acid-Iron Modified Gold Electrode.  International Journal of Electrochemical Science,  (3814).  [PMID:] [10.1016/S1452-3981(23)14433-6]
2. Zhenzhen Zhang, Lingling Yang, Ya Li, Di Sun, Rong Chen, Shengqian Dou, Ting Liu, Sai Zhang, Qingjun Zhou, Lixin Xie.  (2023)  Interference of sympathetic overactivation restores limbal stem/progenitor cells function and accelerates corneal epithelial wound healing in diabetic mice.  BIOMEDICINE & PHARMACOTHERAPY,  161  (114523).  [PMID:36931034] [10.1016/j.biopha.2023.114523]
3. Fang-Nan Wu, Jian Zhu, Guo-Jun Weng, Jian-Jun Li, Xue-Wu Chen, Jun-Wu Zhao.  (2023)  Electron transfer-based norepinephrine detection with high sensitivity regulated by polyethyleneimine molecular weight.  SENSORS AND ACTUATORS B-CHEMICAL,  379  (133297).  [PMID:] [10.1016/j.snb.2023.133297]
4. Huang Yue, Wu Xiangyan, Wu Meizhu, Chu Jianfeng, Yu Na, Shen Aling, Shen Zhiqing, Chen Youqin, Peng Jun.  (2019)  Antihypertensive and Vasodilatory Effects of Qingda Granules by Suppression of Calcium Influx and the AKT Pathway.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,  74  (6): (549).  [PMID:31809404] [10.1097/FJC.0000000000000686]
5. Yijia Tang, Siming Huang, Jianqiao Xu, Gangfeng Ouyang, Yuan Liu.  (2018)  PLGA-based nanofibers with a biomimetic polynoradrenaline sheath for rapid in vivo sampling of tetrodotoxin and sulfonamides in pufferfish.  Journal of Materials Chemistry B,  (22): (3655-3664).  [PMID:32254828] [10.1039/C8TB00757H]
6. Xiao Deli, Liu Shubo, Liang Liyun, Bi Yanping.  (2016)  Magnetic restricted-access microspheres for extraction of adrenaline, dopamine and noradrenaline from biological samples.  MICROCHIMICA ACTA,  183  (4): (1417-1423).  [PMID:] [10.1007/s00604-016-1768-9]
7. Tao Qian, Chenfei Yu, Xi Zhou, Shishan Wu, Jian Shen.  (2014)  Au nanoparticles decorated polypyrrole/reduced graphene oxide hybrid sheets for ultrasensitive dopamine detection.  SENSORS AND ACTUATORS B-CHEMICAL,  193  (759).  [PMID:] [10.1016/j.snb.2013.12.055]

References

1. Lin Liu, Guifang Wang, Qingqin Feng, Yun Xing, Hongxing Han, Min Jing.  (2013)  Specific and Amplified Voltammetric Detection of Dopamine at Nitrilotriacetic acid-Iron Modified Gold Electrode.  International Journal of Electrochemical Science,  (3814).  [PMID:] [10.1016/S1452-3981(23)14433-6]
2. Zhenzhen Zhang, Lingling Yang, Ya Li, Di Sun, Rong Chen, Shengqian Dou, Ting Liu, Sai Zhang, Qingjun Zhou, Lixin Xie.  (2023)  Interference of sympathetic overactivation restores limbal stem/progenitor cells function and accelerates corneal epithelial wound healing in diabetic mice.  BIOMEDICINE & PHARMACOTHERAPY,  161  (114523).  [PMID:36931034] [10.1016/j.biopha.2023.114523]
3. Fang-Nan Wu, Jian Zhu, Guo-Jun Weng, Jian-Jun Li, Xue-Wu Chen, Jun-Wu Zhao.  (2023)  Electron transfer-based norepinephrine detection with high sensitivity regulated by polyethyleneimine molecular weight.  SENSORS AND ACTUATORS B-CHEMICAL,  379  (133297).  [PMID:] [10.1016/j.snb.2023.133297]
4. Huang Yue, Wu Xiangyan, Wu Meizhu, Chu Jianfeng, Yu Na, Shen Aling, Shen Zhiqing, Chen Youqin, Peng Jun.  (2019)  Antihypertensive and Vasodilatory Effects of Qingda Granules by Suppression of Calcium Influx and the AKT Pathway.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,  74  (6): (549).  [PMID:31809404] [10.1097/FJC.0000000000000686]
5. Yijia Tang, Siming Huang, Jianqiao Xu, Gangfeng Ouyang, Yuan Liu.  (2018)  PLGA-based nanofibers with a biomimetic polynoradrenaline sheath for rapid in vivo sampling of tetrodotoxin and sulfonamides in pufferfish.  Journal of Materials Chemistry B,  (22): (3655-3664).  [PMID:32254828] [10.1039/C8TB00757H]
6. Xiao Deli, Liu Shubo, Liang Liyun, Bi Yanping.  (2016)  Magnetic restricted-access microspheres for extraction of adrenaline, dopamine and noradrenaline from biological samples.  MICROCHIMICA ACTA,  183  (4): (1417-1423).  [PMID:] [10.1007/s00604-016-1768-9]
7. Tao Qian, Chenfei Yu, Xi Zhou, Shishan Wu, Jian Shen.  (2014)  Au nanoparticles decorated polypyrrole/reduced graphene oxide hybrid sheets for ultrasensitive dopamine detection.  SENSORS AND ACTUATORS B-CHEMICAL,  193  (759).  [PMID:] [10.1016/j.snb.2013.12.055]

Solution Calculators