Noradrenaline bitartrate monohydrate - ≥98%(HPLC),USP, high purity , CAS No.108341-18-0

Item Number
N107258
Grouped product items
SKUSizeAvailabilityPrice Qty
N107258-200mg
200mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$60.90
N107258-250mg
250mg
In stock
$65.90
N107258-1g
1g
In stock
$216.90
N107258-5g
5g
In stock
$640.90
N107258-25g
25g
In stock
$2,884.90

Endogenous α adrenoceptor agonist

Basic Description

SynonymsNoradrenaline (as tartrate) | (-)-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate | Norepinephrine (Bitartrate) | 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt), monohydr
Specifications & PurityPharmPure™, USP, ≥98%(HPLC)
Biochemical and Physiological MechanismsL-Noradrenaline Bitartrate Monohydrate is a demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland.Autonomic nervous system neurotransmitter released by sympathetic nerve terminals.
Storage TempStore at 2-8°C
Shipped InWet ice
GradePharmPure™, USP
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
A demethylated precursor of epinephrine.

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate
INCHI InChI=1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1
InChi Key LNBCGLZYLJMGKP-LUDZCAPTSA-N
Canonical SMILES C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
Isomeric SMILES C1=CC(=C(C=C1[C@H](CN)O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.O
WGK Germany 3
RTECS DN6750000
Alternate CAS 51-40-1
PubChem CID 3047796
Molecular Weight 337.28
Beilstein 4078502

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
J2312161Certificate of AnalysisOct 19, 2023 N107258
J2312519Certificate of AnalysisOct 19, 2023 N107258
F2305664Certificate of AnalysisApr 27, 2023 N107258
F2305665Certificate of AnalysisApr 27, 2023 N107258
F2305667Certificate of AnalysisApr 27, 2023 N107258
F2305673Certificate of AnalysisApr 27, 2023 N107258
F2305674Certificate of AnalysisApr 27, 2023 N107258
D2324765Certificate of AnalysisMar 23, 2023 N107258
D2324794Certificate of AnalysisMar 23, 2023 N107258

Chemical and Physical Properties

SolubilityDMSO 64 mg/mL;Water 64 mg/mL;Ethanol <1 mg/mL
SensitivityLight sensitive.
Specific Rotation[α]-10.0 to -12.0 deg(C=5, H2O)
Melt Point(°C)129 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS DN6750000

Related Documents

Citations of This Product

1. Yingying Lei, Khaista Rahman, Xiaojian Cao, Bing Yang, Wei Zhou, Aikebaier Reheman, Luxia Cai, Yifan Wang, Rohit Tyagi, Zhe Wang, Xi Chen, Gang Cao.  (2023)  Epinephrine Stimulates Mycobacterium tuberculosis Growth and Biofilm Formation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (24): (17370).  [PMID:38139199] [10.3390/ijms242417370]
2. Haiying Shen, Lianhua Dong, Yunhua Gao, Xia Wang, Xinhua Dai.  (2023)  Integrated Microwell Array-Based Microfluidic Chip with a Hand-Held Smartphone-Controlled Device for Nucleic Acid Detection.  ANALYTICAL CHEMISTRY,  95  (41): (15394–15399).  [PMID:37787984] [10.1021/acs.analchem.3c03525]
3. Yong Liu, Mingzhu Yang, Juanjuan Li, Wei Zhang, Xingyu Jiang.  (2019)  Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging.  ANALYTICAL CHEMISTRY,  91  (10): (6754–6760).  [PMID:31006238] [10.1021/acs.analchem.9b00837]
4. Xia Zhou, Miao Qin, Jun Zhu, Cong Wang, Guang Zhu, Hongyan Wang, Liangbao Yang.  (2018)  Rapid and sensitive surface-enhanced resonance Raman spectroscopy detection for norepinephrine in biofluids.  JOURNAL OF RAMAN SPECTROSCOPY,  50  (3): (314-321).  [PMID:] [10.1002/jrs.5519]
5. Xiaomin Cao, Miao Qin, Pan Li, Binbin Zhou, Xianghu Tang, Meihong Ge, Liangbao Yang, Jinhuai Liu.  (2018)  Probing catecholamine neurotransmitters based on iron-coordination surface-enhanced resonance Raman spectroscopy label.  SENSORS AND ACTUATORS B-CHEMICAL,  268  (350).  [PMID:] [10.1016/j.snb.2018.04.117]
6. Haiying Shen, Feng Qu, Yong Xia, Xingyu Jiang.  (2018)  Straightforward and Ultrastable Surface Modification of Microfluidic Chips with Norepinephrine Bitartrate Improves Performance in Immunoassays.  ANALYTICAL CHEMISTRY,  90  (6): (3697–3702).  [PMID:29478312] [10.1021/acs.analchem.7b05186]

References

1. Yang B et al..  (2021)  Locus coeruleus anchors a trisynaptic circuit controlling fear-induced suppression of feeding..  Neuron,  109  (5): (823-838.e6).  [PMID:33476548]
2. Gao XJ et al..  (2020)  Multi-in-One: Multiple-proteases, One-hour-shot Strategy for Fast and High-coverage Phosphoproteomic Investigation..  Anal Chem,      [PMID:32479063]
3. Honda K et al..  (2021)  On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity..  Redox Biol,  41  (101926).  [PMID:33752108]
4. Rajalingam D et al..  (2021)  Workplace bullying increases the risk of anxiety through a stress-induced ß2-adrenergic receptor mechanism: a multisource study employing an animal model, cell culture experiments and human data..  Int Arch Occup Environ Health,  94  (8): (1905-1915).  [PMID:34076732]
5. Yingying Lei, Khaista Rahman, Xiaojian Cao, Bing Yang, Wei Zhou, Aikebaier Reheman, Luxia Cai, Yifan Wang, Rohit Tyagi, Zhe Wang, Xi Chen, Gang Cao.  (2023)  Epinephrine Stimulates Mycobacterium tuberculosis Growth and Biofilm Formation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (24): (17370).  [PMID:38139199] [10.3390/ijms242417370]
6. Haiying Shen, Lianhua Dong, Yunhua Gao, Xia Wang, Xinhua Dai.  (2023)  Integrated Microwell Array-Based Microfluidic Chip with a Hand-Held Smartphone-Controlled Device for Nucleic Acid Detection.  ANALYTICAL CHEMISTRY,  95  (41): (15394–15399).  [PMID:37787984] [10.1021/acs.analchem.3c03525]
7. Yong Liu, Mingzhu Yang, Juanjuan Li, Wei Zhang, Xingyu Jiang.  (2019)  Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging.  ANALYTICAL CHEMISTRY,  91  (10): (6754–6760).  [PMID:31006238] [10.1021/acs.analchem.9b00837]
8. Xia Zhou, Miao Qin, Jun Zhu, Cong Wang, Guang Zhu, Hongyan Wang, Liangbao Yang.  (2018)  Rapid and sensitive surface-enhanced resonance Raman spectroscopy detection for norepinephrine in biofluids.  JOURNAL OF RAMAN SPECTROSCOPY,  50  (3): (314-321).  [PMID:] [10.1002/jrs.5519]
9. Xiaomin Cao, Miao Qin, Pan Li, Binbin Zhou, Xianghu Tang, Meihong Ge, Liangbao Yang, Jinhuai Liu.  (2018)  Probing catecholamine neurotransmitters based on iron-coordination surface-enhanced resonance Raman spectroscopy label.  SENSORS AND ACTUATORS B-CHEMICAL,  268  (350).  [PMID:] [10.1016/j.snb.2018.04.117]
10. Haiying Shen, Feng Qu, Yong Xia, Xingyu Jiang.  (2018)  Straightforward and Ultrastable Surface Modification of Microfluidic Chips with Norepinephrine Bitartrate Improves Performance in Immunoassays.  ANALYTICAL CHEMISTRY,  90  (6): (3697–3702).  [PMID:29478312] [10.1021/acs.analchem.7b05186]

Solution Calculators