Basic Description

Synonyms	29745-04-8 \| CHEMBL298246 \| 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aR,4S,7R,7aS)-rel- \| 8452E71EO7 \| rel-(3aR,4R,7S,7aS)-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione \| ( inverted exclamation markA)-Norcantharidin \| (1R,2S,6R,7S)-4,10-DIOXATRICYCLO[5.2.1.0,2,6]
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

PPP1CC Tchem Serine/threonine protein phosphatase PP1-gamma catalytic subunit (63 Activities)

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Homo sapiens (32628 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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KB 3-1 (1143 Activities)

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MCF7 (126967 Activities)

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SW480 (6023 Activities)

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A-431 (6446 Activities)

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HCT-116 (91556 Activities)

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Colon cancer cell line (58 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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A2780 (11979 Activities)

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Jurkat (10389 Activities)

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MDA-MB-231 (73002 Activities)

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BT-549 (31254 Activities)

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Associated Targets(non-human)

Serine-threonine protein phosphatase 2A regulatory subunit (96 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1R,2S,6R,7S)-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione
INCHI	InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4+,5-,6+
InChi Key	JAABVEXCGCXWRR-FBXFSONDSA-N
Canonical SMILES	C1CC2C3C(C1O2)C(=O)OC3=O
Isomeric SMILES	C1C[C@H]2[C@H]3[C@@H]([C@@H]1O2)C(=O)OC3=O
PubChem CID	9877482
Molecular Weight	168.15

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Moisture sensitive
Melt Point(°C)	111-117（℃）

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jia Wang, Xiange Huang, Hegen Li, Deyue Yan, Wei Huang. (2022) Two Zn(II) coordination polymers with anticancer drug norcantharidin as ligands for cancer chemotherapy. DALTON TRANSACTIONS, 51 (14): (5624-5634). [PMID:35319055] [10.1039/D2DT00300G]
2. Shiqiang Zhang, Yun Yang, Yunwei Hua, Chen Hu, Yi Zhong. (2020) NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling. Molecular Medicine Reports, 22 (2): (774-782). [PMID:32468032] [10.3892/mmr.2020.11151]
3. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

References

1. Jia Wang, Xiange Huang, Hegen Li, Deyue Yan, Wei Huang. (2022) Two Zn(II) coordination polymers with anticancer drug norcantharidin as ligands for cancer chemotherapy. DALTON TRANSACTIONS, 51 (14): (5624-5634). [PMID:35319055] [10.1039/D2DT00300G]
2. Shiqiang Zhang, Yun Yang, Yunwei Hua, Chen Hu, Yi Zhong. (2020) NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling. Molecular Medicine Reports, 22 (2): (774-782). [PMID:32468032] [10.3892/mmr.2020.11151]
3. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

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Norcantharidin - 10mM in DMSO, high purity , CAS No.29745-04-8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator