Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N129448-1g | 1g | In stock | $128.90 | |
N129448-5g | 5g | In stock | $513.90 | |
N129448-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,308.90 |
Potent synthetic progestin
Synonyms | SC 4640 | Brevinor-1 28 | Estrinor | Nodiol | Norcolut | Norethynodron | Norethynodrone | Triella | BRN 1915671 | Norpregneninlone | Synphase | 17-alpha-Ethynyl-4-estren-17-ol-3-one | 17alpha-Ethynyl-4-estren-17-ol-3-one | HSDB 3370 | Mini-Pe | Ethynylmor |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Norethindrone is a synthetic progestin which in low doses is progestational and in high doses is antiestrogenic. Norethindrone also causes a time-dependent loss of cytochrome P-450 when incubated in vitro with rat liver microsomal fractions in NADPH-gener |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Progesterone receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone. |
ALogP | 3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
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INCHI | InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 |
InChi Key | VIKNJXKGJWUCNN-XGXHKTLJSA-N |
Canonical SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34 |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34 |
WGK Germany | 3 |
RTECS | RC8975000 |
PubChem CID | 6230 |
Molecular Weight | 298.42 |
Beilstein | 1915671 |
ChEMBL Ligand | CHEMBL1162 |
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CAS Registry No. | 68-22-4 |
DrugBank Ligand | DB00717 |
Wikipedia | Norethisterone |
PubChem CID | 6230 |
RCSB PDB Ligand | NDR |
PEP | norethisterone |
DrugCentral Ligand | 1962 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J2218056 | Certificate of Analysis | Jun 28, 2024 | N129448 |
J2218183 | Certificate of Analysis | Jun 28, 2024 | N129448 |
J2218232 | Certificate of Analysis | Jun 28, 2024 | N129448 |
C2116235 | Certificate of Analysis | Jan 11, 2023 | N129448 |
Solubility | DMSO 60 mg/mL Water <1 mg/mL Ethanol 5 mg/mL |
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Sensitivity | light sensitive |
Refractive Index | 1.58 |
Boil Point(°C) | ~446.98° C at 760 mmHg |
Melt Point(°C) | 205-206°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | RC8975000 |
1. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] [10.1016/j.talanta.2023.124589] |
2. Qianyu Li, Guoliang Li, Lihua Fan, Yanxin Yu, Jin Liu. (2022) Click reaction triggered turn-on fluorescence strategy for highly sensitive and selective determination of steroid hormones in food samples. FOOD CHEMISTRY, 374 (131565). [PMID:34875430] [10.1016/j.foodchem.2021.131565] |
1. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] [10.1016/j.talanta.2023.124589] |
2. Qianyu Li, Guoliang Li, Lihua Fan, Yanxin Yu, Jin Liu. (2022) Click reaction triggered turn-on fluorescence strategy for highly sensitive and selective determination of steroid hormones in food samples. FOOD CHEMISTRY, 374 (131565). [PMID:34875430] [10.1016/j.foodchem.2021.131565] |