Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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N114262-5g | 5g | In stock | $16.90 | |
N114262-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $22.90 | |
N114262-25g | 25g | In stock | $43.90 | |
N114262-100g | 100g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $99.90 | |
N114262-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $299.90 |
Broad spectrum antibacterial agent
Synonyms | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid | Sebercim | Baccidal | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase). Mode of action: inhibits bacterial DNA replication Antimicrobial spectrum: Gram-negative bacteria; less effective |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Chemical structure: fluoroquinolone Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria. |
ALogP | -1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid |
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INCHI | InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) |
InChi Key | OGJPXUAPXNRGGI-UHFFFAOYSA-N |
Canonical SMILES | CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O |
Isomeric SMILES | CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O |
PubChem CID | 4539 |
Molecular Weight | 319.33 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2425452 | Certificate of Analysis | Nov 14, 2024 | N114262 |
K2425451 | Certificate of Analysis | Nov 14, 2024 | N114262 |
K2425433 | Certificate of Analysis | Nov 14, 2024 | N114262 |
K2425432 | Certificate of Analysis | Nov 14, 2024 | N114262 |
J2410488 | Certificate of Analysis | Sep 23, 2024 | N114262 |
J2410487 | Certificate of Analysis | Sep 23, 2024 | N114262 |
J2410486 | Certificate of Analysis | Sep 23, 2024 | N114262 |
J2410485 | Certificate of Analysis | Sep 23, 2024 | N114262 |
J2410489 | Certificate of Analysis | Sep 23, 2024 | N114262 |
D2422152 | Certificate of Analysis | Apr 09, 2024 | N114262 |
H2416047 | Certificate of Analysis | Apr 09, 2024 | N114262 |
H2416034 | Certificate of Analysis | Apr 09, 2024 | N114262 |
D2422155 | Certificate of Analysis | Apr 09, 2024 | N114262 |
D2422154 | Certificate of Analysis | Apr 09, 2024 | N114262 |
D2422153 | Certificate of Analysis | Apr 09, 2024 | N114262 |
D2422151 | Certificate of Analysis | Apr 09, 2024 | N114262 |
D2422150 | Certificate of Analysis | Apr 09, 2024 | N114262 |
L2318065 | Certificate of Analysis | Dec 22, 2023 | N114262 |
L2116209 | Certificate of Analysis | Sep 19, 2023 | N114262 |
L2116215 | Certificate of Analysis | Sep 19, 2023 | N114262 |
L2116290 | Certificate of Analysis | Sep 19, 2023 | N114262 |
D2129073 | Certificate of Analysis | Feb 08, 2023 | N114262 |
D2129072 | Certificate of Analysis | Feb 08, 2023 | N114262 |
G2314166 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031258 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031237 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031213 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031209 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031205 | Certificate of Analysis | Feb 07, 2023 | N114262 |
D23031190 | Certificate of Analysis | Feb 07, 2023 | N114262 |
A2426041 | Certificate of Analysis | Feb 07, 2023 | N114262 |
K2009084 | Certificate of Analysis | Sep 12, 2022 | N114262 |
H1816036 | Certificate of Analysis | Apr 27, 2022 | N114262 |
Solubility | Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water |
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Melt Point(°C) | 227-228°C |
Pictogram(s) | GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H318:Causes serious eye damage H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. |
Merck Index | 6700 |
Starting at $69.90
Starting at $308.90
1. Xiaomeng Liu, Yitian Zhong, Haosheng Feng, Yanxi Zhao, Qin Li, Tao Huang. (2023) Synthesis of a novel AgI/BiOI nanocomposites and their high-efficiency visible-light driven photocatalytic degradation performance for norfloxacin. NEW JOURNAL OF CHEMISTRY, (15): [PMID:2174397] [10.1039/D3NJ05037H] |
2. Xuefang Zhao, Hui Xu, Minzhang Chen, Yong Chen, Xiuqing Kong. (2024) Enhancement of norfloxacin degradation by citrate in S-nZVI@Ps system: Chelation and FeS layer. ENVIRONMENTAL RESEARCH, 245 (117981). [PMID:38142729] [10.1016/j.envres.2023.117981] |
3. Ziyue Xi, Yingying Jiang, Zitong Ma, Qun Li, Xinran Xi, Chuanyong Fan, Shuang Zhu, Junjie Zhang, Lu Xu. (2023) Using Mesoporous Silica-Based Dual Biomimetic Nano-Erythrocytes for an Improved Antitumor Effect. Pharmaceutics, 15 (12): (2785). [PMID:38140125] [10.3390/pharmaceutics15122785] |
4. Zhiwei Yang, Yiwen Luo, Yihan Chen, Jing Zhang, Xinyu Wang, Xianchun Chen. (2024) In-situ formation of Ni2P on black phosphorus surface for efficient NIR photocatalytic singlet oxygen generation. JOURNAL OF CATALYSIS, 429 (115254). [PMID:] [10.1016/j.jcat.2023.115254] |
5. Shitong Liu, Jun Wang, Yang Liu, Baojun Yang, Maoxin Hong, Shichao Yu, Guanzhou Qiu. (2024) Degradation of norfloxacin by red mud-based prussian blue activating H2O2: A strategy for treating waste with waste. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 269 (115794). [PMID:38061084] [10.1016/j.ecoenv.2023.115794] |
6. Zhiwei Yang, Jing Zhang, Xixi Sun, Xinyu Wang, Yueqi Pan, Jiagang Wu, Xianchun Chen. (2024) Piezoelectric charges elicited a chain reaction of sulfite activation: Performance and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, 332 (10): (125711). [PMID:24656813] [10.1016/j.seppur.2023.125711] |
7. Kui Yang, Xinyuan Zhang, Daoyuan Zu, Hongjian Zhou, Jinxing Ma, Zhifeng Yang. (2023) Shifting Emphasis from Electro- to Catalytically Active Sites: Effects of Pore Size of Flow-Through Anodes on Water Purification. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (48): (20421–20430). [PMID:37971949] [10.1021/acs.est.3c07448] |
8. Luwei Zhai, Fengchun Li, Yuhai He, Xia Chen, Xuan Zhang, Yawei Gu, Chongqing Xu, Guihuan Yan, Xiaojing Feng, Wenqiang Jiang. (2023) Degradation of norfloxacin by sulfur-doped iron-cobalt oxides activated perodisulfate: Synergism between free radicals and singlet oxygen. CHEMICAL ENGINEERING JOURNAL, 478 (147378). [PMID:15084671] [10.1016/j.cej.2023.147378] |
9. Xin-Yu Liu, Xiao-Yun Gu, Chen Liu, Lanre Anthony Gbadegesin, Yang He, Jian-Qiang Zhang. (2024) Field migration of veterinary antibiotics via surface runoff from chicken-raising orchard in responding to natural rainfalls. SCIENCE OF THE TOTAL ENVIRONMENT, 909 (25): (168527). [PMID:37967624] [10.1016/j.scitotenv.2023.168527] |
10. Qi Pu, Lu Zhang, Nengsheng Ye, Yuhong Xiang. (2024) Lanthanide coordination carbon quantum dots construct a ratiometric fluorescent sensor for the detection of norfloxacin in milk. DYES AND PIGMENTS, 222 (111815). [PMID:2576652] [10.1016/j.dyepig.2023.111815] |
11. Qian Han, Ling Fan, Xiuying Liu, Yiwei Tang, Pingping Wang, Zaixi Shu, Wei Zhang, Lijie Zhu. (2023) Lateral Flow Immunoassay Based on Quantum-Dot Nanobeads for Detection of Chloramphenicol in Aquatic Products. MOLECULES, 28 (22): (7496). [PMID:38005218] [10.3390/molecules28227496] |
12. Lingjun Geng, Jiashuai Sun, Mengyue Liu, Jingcheng Huang, Jiwei Dong, Zhen Guo, Yemin Guo, Xia Sun. (2024) Molecularly imprinted polymers-aptamer electrochemical sensor based on dual recognition strategy for high sensitivity detection of chloramphenicol. FOOD CHEMISTRY, 437 (137933). [PMID:37951077] [10.1016/j.foodchem.2023.137933] |
13. Huang Jialu, Zhang Shuchi, Tan Mengyu, Shen Jie, Zhao Haiyan, Wu Donglei. (2023) Occurrence, removal, and risk assessment of emerging contaminants in aquatic products processing sewage treatment plants. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, (11): (1-13). [PMID:37874520] [10.1007/s11356-023-30458-z] |
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16. Jinming Feng, Jincheng Mu, Qiong Peng, Yang Xiao, Baojun Liu. (2023) In situ interfacial engineering modulated adsorption and electron transfer boosting peroxymonosulfate activation for micro-contaminates degradation over CoOx nanosheet. CHEMICAL ENGINEERING JOURNAL, 476 (146724). [PMID:25996873] [10.1016/j.cej.2023.146724] |
17. Yin Wang, Huanhuan Li, Jin Xu, Jiayu Yu, Jinfeng Wang, Hu Jiang, Chengyun Li, Xiaodong Zhang, Ning Liu. (2024) High-performance carbon@ metal oxide nanocomposites derived metal–organic framework-perovskite hybrid boosted microwave-induced catalytic degradation of norfloxacin: Performance, degradation pathway and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (5): (125399). [PMID:9482110] [10.1016/j.seppur.2023.125399] |
18. Guangli Li, Xiaoman Qi, Jingtao Wu, Xuan Wan, Tianyu Wang, Ying Liu, Yuwei Chen, Yonghui Xia. (2024) Highly stable electrochemical sensing platform for the selective determination of pefloxacin in food samples based on a molecularly imprinted-polymer-coated gold nanoparticle/black phosphorus nanocomposite. FOOD CHEMISTRY, 436 (137753). [PMID:37862994] [10.1016/j.foodchem.2023.137753] |
19. Jingjing Hu, Wei Cheng, Yishuo Zhao, Yian Song, Huan Xu, Hao Zhou, Huifang Yang, Jie Sun, Ruan Chi. (2024) The synergistic effect of oxygen vacancies and acidic properties of SO42−/CexZr1−xO2 on enhancing the Electro-Fenton performance in antibiotics wastewater treatment. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (125233). [PMID:7655467] [10.1016/j.seppur.2023.125233] |
20. Changyou Wang, Yiwen Xu, Haifeng Gu, Zhaohe Luo, Zhuhua Luo, Rongguo Su. (2024) Potential geographical distribution of harmful algal blooms caused by the toxic dinoflagellate Karenia mikimotoi in the China Sea. SCIENCE OF THE TOTAL ENVIRONMENT, 906 (167741). [PMID:37827322] [10.1016/j.scitotenv.2023.167741] |
21. Yuanli Xu, Wenlin Feng. (2024) MUA/NPAM/ZnO-coated Fiber-Optic surface plasmon resonance sensor for trace Chromium-Ion detection. OPTICS AND LASER TECHNOLOGY, 169 (30): (110184). [PMID:12787504] [10.1016/j.optlastec.2023.110184] |
22. Yujie He, Zhongjing Zhao, Tao Wang, Lichao An, Lu Zhang. (2023) Carbon-based materials as efficient adsorbents for the removal of antibiotics: The real contributions of carbon edge sites. CHEMOSPHERE, 344 (2): (140341). [PMID:37778643] [10.1016/j.chemosphere.2023.140341] |
23. Yang Weiqing, Li Dandan, Li Yunlong, Zheng Yuan, Shan Jiajia. (2023) Synthesis of a capillary surface-enhanced Raman scattering substrate integrating sampling and detection based on meniscus self-assembled technology. MICROCHIMICA ACTA, 190 (10): (1-9). [PMID:37737867] [10.1007/s00604-023-05981-y] |
24. Xiaoqian Peng, Yingyi Li, Kairuo Zhu, Qingda An, Jingai Hao, Zuoyi Xiao, Xiaoling Dong, Shangru Zhai. (2023) CoSx produced in Porphyra biochar by exogenous Co and endogenous S doping to enhance peroxymonosulfate activation for carbamazepine degradation. Journal of Environmental Chemical Engineering, 11 (110988). [PMID:20154705] [10.1016/j.jece.2023.110988] |
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