Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N612368-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
N612368-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
N612368-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $139.90 | |
N612368-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $219.90 | |
N612368-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $349.90 |
Synonyms | BIDD:PXR0187 | 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene | Nortriptylinum (INN-Latin) | KBio2_001521 | Spectrum4_000455 | Spectrum_001041 | SPECTRUM1500442 | 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-me |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Channel blocker of K ir3.2;Channel blocker of K ir3.4;Channel blocker of K ir4.1;Inhibitor of NET;Inhibitor of SERT |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine |
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INCHI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
InChi Key | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
Canonical SMILES | CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
Isomeric SMILES | CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
Alternate CAS | 72-69-5;894-71-3 |
PubChem CID | 4543 |
NSC Number | 757234 |
MeSH Entry Terms | Allegron;Apo Nortriptyline;Apo-Nortriptyline;Aventyl;Desitriptyline;Desmethylamitriptylin;Gen Nortriptyline;Gen-Nortriptyline;Hydrochloride, Nortriptyline;Norfenazin;Nortrilen;Nortriptyline;Nortriptyline Hydrochloride;Novo Nortriptyline;Novo-Nortriptyline |
Molecular Weight | 263.38 |
PubChem CID | 4543 |
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DrugBank Ligand | DB00540 |
CAS Registry No. | 72-69-5 |
ChEBI | CHEBI:7640 |
Wikipedia | Nortriptyline |
ChEMBL Ligand | CHEMBL445 |
BindingDB Ligand | 50020710 |
RCSB PDB Ligand | 21B |
PEP | nortriptyline |
DrugCentral Ligand | 1971 |
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Sensitivity | Light sensitive |
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Starting at $182.90
Starting at $9.90