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SKU

Size

Availability

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N136755-1g

In stock

$9.90

N136755-5g

In stock

$34.90

Basic Description

Synonyms	Altilev \| Nortriptyline (hydrochloride) \| Tox21_110048 \| Nortriptyline hydrochloride (USAN:USP:JAN) \| NSC78248 \| NSC-78248 \| D00816 \| Nortriptyline for system suitability \| REGID_for_CID_441358 \| Tox21_500868 \| HY-B1417 \| MLS001077267 \| Norzepine \| 3-(10,
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Norepinephrine transporter inhibitor

Associated Targets(Human)

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

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KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
INCHI	InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChi Key	SHAYBENGXDALFF-UHFFFAOYSA-N
Canonical SMILES	CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Isomeric SMILES	CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
WGK Germany	3
RTECS	HP0175000
PubChem CID	441358
Molecular Weight	299.84
Reaxy-Rn	4163872

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
K2103330	Certificate of Analysis	Aug 04, 2023	N136755
K2103332	Certificate of Analysis	Aug 04, 2023	N136755

Chemical and Physical Properties

Solubility	ethanol: 100 mg/mL H2O: soluble
Sensitivity	Sensitive to light
Melt Point(°C)	218 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	HP0175000
Reaxy-Rn	4163872
Merck Index	6715

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Rui-qing Wang, Ying-jie He, Yuan-yuan Xiao, De-xiang Sun, Jing-hui Yang, Xiao-dong Qi, Yong Wang. (2023) Weavable phase change fibers with wide thermal management temperature range, reversible thermochromic and triple shape memory functions towards human thermal management. EUROPEAN POLYMER JOURNAL, 187 (111890). [PMID:]

References

1. Rui-qing Wang, Ying-jie He, Yuan-yuan Xiao, De-xiang Sun, Jing-hui Yang, Xiao-dong Qi, Yong Wang. (2023) Weavable phase change fibers with wide thermal management temperature range, reversible thermochromic and triple shape memory functions towards human thermal management. EUROPEAN POLYMER JOURNAL, 187 (111890). [PMID:]

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Nortriptyline Hydrochloride - ≥98% (HPLC), high purity , Norepinephrine transporter inhibitor, CAS No.894-71-3, Norepinephrine transporter inhibitor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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