Notch inhibitor 1 - 99%, high purity , CAS No.1584647-27-7

Item Number

N649818

Grouped product items
SKU	Size	Availability	Price	Qty
N649818-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,950.90
N649818-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,400.90

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Basic Description

Synonyms	Butanediamide, N1-((3S)-5-(3-fluorophenyl)-2,3-dihydro-9-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)-, (2R,3S)- \| SCHEMBL15608290 \| (2S,3R)-N'-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3
Specifications & Purity	99%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Notch inhibitor 1 is a potent Notch inhibitor, with IC 50 s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer In Vitro Notch inhibitor 1 (Example 1) potently inhibits Notch signaling pathway. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 7.8 nM (Notch 1), 8.5 nM (Notch 3)

Associated Targets(Human)

NOTCH3 Tchem Neurogenic locus notch homolog protein 3 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOTCH1 Tchem Neurogenic locus notch homolog protein 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOTCH1 Tchem Neurogenic locus notch homolog protein 1 (161 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NOTCH3 Tchem Neurogenic locus notch homolog protein 3 (57 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S,3R)-N'-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide
INCHI	InChI=1S/C26H25F7N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
InChi Key	SRJNRAQUSAVENA-GSHUGGBRSA-N
Canonical SMILES	CC1=C2C(=CC=C1)C(=NC(C(=O)N2)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F
Isomeric SMILES	CC1=C2C(=CC=C1)C(=N[C@@H](C(=O)N2)NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F
Alternate CAS	1584647-27-7
PubChem CID	73388393
MeSH Entry Terms	(2R,3S)-N-((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide;BMS-986115;butanediamide, N1-((3S)-5-(3-fluorophenyl)-2,3-dihydro-9-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-tr
Molecular Weight	574.49

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Basic Description