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NP118809 - ≥98%, high purity , Voltage-gated N-type calcium channel alpha-1B subunit blocker, CAS No.41332-24-5, Voltage-gated N-type calcium channel alpha-1B subunit blocker

Moligand™
≥98%

CAS#: 41332-24-5
Formula: C₃₂H₃₂N₂O
Molecular Weight: 460.61
PubChem CID: 4988454

Item Number

N125978

Grouped product items
SKU	Size	Availability	Price
N125978-5mg	5mg	In stock	$9.90
N125978-10mg	10mg	In stock	$16.90
N125978-25mg	25mg	In stock	$34.90
N125978-50mg	50mg	In stock	$57.90
N125978-100mg	100mg	In stock	$94.90
N125978-250mg	250mg	In stock	$121.90
N125978-500mg	500mg	In stock	$147.90
N125978-1g	1g	In stock	$266.90

View related series

Cav2.2 Gating inhibitor

Basic Description

Synonyms	41332-24-5\|NP118809\|1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone\|NP-118809\|Z-160\|1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one\|Z160\|Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-\|MK-6721\|TX3R141LEP\|NMED-160\|39-1B4\|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	In Vitro：NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM. In Vivo：NP118809 (25 mg
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	BLOCKER, GATING INHIBITOR
Mechanism of action	Voltage-gated N-type calcium channel alpha-1B subunit blocker

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Discover Target: CNR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1H Tclin Voltage-dependent T-type calcium channel subunit alpha-1H 0 Activities

Discover Target: CACNA1H

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1B Tclin Voltage-dependent N-type calcium channel subunit alpha-1B 1 Activities

Discover Target: CACNA1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA2D1 Tclin Voltage-dependent calcium channel subunit alpha-2/delta-1 0 Activities

Discover Target: CACNA2D1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one
INCHI	InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2
InChi Key	VCPMZDWBEWTGNW-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5
PubChem CID	4988454
Molecular Weight	460.61

PubChem CID

4988454

CAS Registry No.

41332-24-5

ChEMBL Ligand

CHEMBL604710

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
B2208157	Certificate of Analysis	Nov 14, 2023	N125978
B2208182	Certificate of Analysis	Nov 14, 2023	N125978
B2208193	Certificate of Analysis	Nov 14, 2023	N125978
B2208207	Certificate of Analysis	Nov 14, 2023	N125978
B2208216	Certificate of Analysis	Nov 14, 2023	N125978
B2208404	Certificate of Analysis	Nov 14, 2023	N125978
B2208406	Certificate of Analysis	Nov 14, 2023	N125978
B2208407	Certificate of Analysis	Nov 14, 2023	N125978

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