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NP118809 - ≥98%, high purity , Voltage-gated N-type calcium channel alpha-1B subunit blocker, CAS No.41332-24-5, Voltage-gated N-type calcium channel alpha-1B subunit blocker
Basic Description Synonyms HY-14462 | UNII-TX3R141LEP | VCPMZDWBEWTGNW-UHFFFAOYSA-N | NP 118809 | NCGC00378879-01 | AKOS003297641 | Z27755997 | 1-[4-[di(phenyl)methyl]piperazin-1-yl]-3,3-di(phenyl)propan-1-one | NMED-160 | CS-1361 | 1-[4-(diphenylmethyl)piperazin-1-yl]-3,3-diphenyl Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms In Vitro：NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM.
In Vivo：NP118809 (25 mg Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type BLOCKER, GATING INHIBITOR Mechanism of action Voltage-gated N-type calcium channel alpha-1B subunit blocker
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one INCHI InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2 InChi Key VCPMZDWBEWTGNW-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5 Isomeric SMILES C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5 PubChem CID 4988454 Molecular Weight 460.61
Chemical and Physical Properties Solubility insoluble in H2O; insoluble in EtOH; ≥63.4 mg/mL in DMSO
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B2208157