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NQ 301 - ≥98%(HPLC), high purity , CAS No.130089-98-4
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective CD45 inhibitor (IC50= 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytesin vitro. Bloc Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-(4-acetylanilino)-3-chloronaphthalene-1,4-dione INCHI InChI=1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 InChi Key LSQZKIQSQHZVQS-UHFFFAOYSA-N Canonical SMILES CC(=O)C1=CC=C(C=C1)NC2=C(C(=O)C3=CC=CC=C3C2=O)Cl Isomeric SMILES CC(=O)C1=CC=C(C=C1)NC2=C(C(=O)C3=CC=CC=C3C2=O)Cl PubChem CID 781109 Molecular Weight 325.75
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 32.58, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS05 , GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H400: Very toxic to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P337+P313: IF eye irritation persists: Get medical advice/attention.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P332+P313: IF SKIN irritation occurs: Get medical advice/attention.
P391: Collect spillage.
P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.
RIDADR UN30779/PGIII
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J2119399