Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H131759-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $22.90 | |
H131759-5mg | 5mg | In stock | $88.90 | |
H131759-25mg | 25mg | In stock | $400.90 | |
H131759-100mg | 100mg | In stock | $1,441.90 |
Potent and selective K Ca 1.1 channel activator
Synonyms | J-009032 | KBio3_000289 | KBio2_002713 | NCGC00015720-11 | NCGC00094210-03 | 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2h-benzimidazol-2-one | NCGC00015720-02 | AS-55902 | HB1048 | NCGC00015720-06 | AMY36458 | 1-(2'-Hydroxy-5 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | NS-1619 is a selective MaxiKα (large conductance calcium activated potassium channel) activator. In neutrophils, NS-1619 activation of BKCa channels increased alkalinization of phagocytic vacuoles.Potent and selective K Ca 1.1 channel activator. Induces a |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of K Ca1.1;Activator of K Ca5.1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[2-hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-one |
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INCHI | InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) |
InChi Key | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O |
Isomeric SMILES | C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O |
PubChem CID | 4552 |
Molecular Weight | 362.23 |
PubChem CID | 4552 |
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CAS Registry No. | 153587-01-0 |
ChEMBL Ligand | CHEMBL384903 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E1704107 | Certificate of Analysis | Dec 08, 2022 | H131759 |
Solubility | Soluble in ethanol (26.6 mg/ml), DMSO (5.3 mg/ml), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.47 mg/ml), and 0.1 M NaOH (5.2 mg/ml). Insoluble in water |
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Sensitivity | Air Sensitive |
Refractive Index | 1.54 |
Melt Point(°C) | 178.44°C |
1. Zhang X et al.. (2022) Effects of KCa channels on biological behavior of trophoblasts.. Open Life Sci, 17 (1043-1052). [PMID:36118166] |
2. Wang M et al.. (2018) Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.. Biomed Res Int, 2018 (2925985). [PMID:29511675] |
3. Zhou Y et al.. (2020) Topology-dependent, bifurcated mitochondrial quality control under starvation.. Autophagy, 16 (3): (562-574). [PMID:31234709] |