NS-1619 is a selective MaxiKα (large conductance calcium activated potassium channel) activator. In neutrophils, NS-1619 activation of BKCa channels increased alkalinization of phagocytic vacuoles.Potent and selective K Ca 1.1 channel activator. Induces a
Shipped In
Normal
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
Activator of K Ca1.1;Activator of K Ca5.1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. A selective large conductance calcium activated potassium channel activator
Soluble in ethanol (26.6 mg/ml), DMSO (5.3 mg/ml), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.47 mg/ml), and 0.1 M NaOH (5.2 mg/ml). Insoluble in water
1.Zhang X et al.. (2022) Effects of KCa channels on biological behavior of trophoblasts.. Open Life Sci, 17 (1043-1052). [PMID:36118166]
2.Wang M et al.. (2018) Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.. Biomed Res Int, 2018 (2925985). [PMID:29511675]
3.Zhou Y et al.. (2020) Topology-dependent, bifurcated mitochondrial quality control under starvation.. Autophagy, 16 (3):(562-574). [PMID:31234709]
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E1704107