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NS 1738 - 98%, high purity , CAS No.501684-93-1, Channel blocker of nicotinic acetylcholine receptor α3 subunit;Channel blocker of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Item Number
N288205
Grouped product items
SKUSizeAvailabilityPrice Qty
N288205-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$15.90
N288205-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$25.90
N288205-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$51.90
N288205-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$83.90
N288205-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$133.90
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Positive allosteric modulator of α7 nAChRs; activein vivo

View related series
nicotinic acetylcholine receptor α3 subunit Channel blocker nicotinic acetylcholine receptor α4 subunit Channel blocker nicotinic acetylcholine receptor α7 subunit Allosteric modulator

Basic Description

SynonymsNS 1738 | 501684-93-1 | NS-1738 | NS1738 | Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)- | NSC-213859 | NSC 213859 | CHEMBL407217 | 9822RX831L | 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea | 1-(5-chloro-2-hydroxypheny
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsSelective positive allosteric modulator ofα7 nicotinic acetylcholine receptors. Exhibits no substantial activity forα4β2,α3β3 andα1-containing receptors. Displays cognitive-enhancing propertiesin vivo.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR, CHANNEL BLOCKER
Mechanism of actionChannel blocker of nicotinic acetylcholine receptor α3 subunit;Channel blocker of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Associated Targets(Human)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRNA3 Tclin Neuronal acetylcholine receptor subunit alpha-3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRNA4 Tclin Neuronal acetylcholine receptor subunit alpha-4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRNA7 Tchem Neuronal acetylcholine receptor protein alpha-7 subunit (3524 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-(5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea
INCHI InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChi Key OUDXRNQPVSMGDW-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl
Isomeric SMILES C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl
PubChem CID 310378
Molecular Weight 365.13

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
L2315322Certificate of AnalysisNov 25, 2023 N288205
L2315323Certificate of AnalysisNov 25, 2023 N288205
L2315324Certificate of AnalysisNov 25, 2023 N288205
L2315325Certificate of AnalysisNov 25, 2023 N288205
L2315326Certificate of AnalysisNov 25, 2023 N288205
L2315327Certificate of AnalysisNov 25, 2023 N288205
L2315328Certificate of AnalysisNov 25, 2023 N288205
L2315329Certificate of AnalysisNov 25, 2023 N288205

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 36.51, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 36.51, Max Conc. mM: 100
Sensitivitylight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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