Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N274713-10mg | 10mg | In stock | $75.90 | |
N274713-25mg | 25mg | In stock | $171.90 | |
N274713-50mg | 50mg | In stock | $245.90 | |
N274713-100mg | 100mg | In stock | $380.90 | |
N274713-250mg | 250mg | In stock | $857.90 | |
N274713-1g | 1g | In stock | $3,086.90 |
COX-2 inhibitor
Synonyms | NS-398 | Bio2_000472 | CCRIS 8523 | N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide | s8433 | C71930 | GTPL8976 | HMS3886L10 | Methanesulfonamide, N-(2-(cyclohexyloxy)-4-nitrophenyl)- | HMS1792P05 | HMS3649O13 | KTDZCOWXCWUPEO-UHFFFAOYSA-N | N-{2-(c |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and >100 μM for COX-2 and COX-1, respectively). Orally active. Anti-inflammatory, antipyretic, analgesic and non-ulcerogenic in vivo . Induces apoptosis and cell cycle arrest. |
Source | Synthetic |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of COX-2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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IUPAC Name | N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide |
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INCHI | InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3 |
InChi Key | KTDZCOWXCWUPEO-UHFFFAOYSA-N |
Canonical SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2 |
Isomeric SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2 |
Alternate CAS | 123653-11-2 |
PubChem CID | 4553 |
MeSH Entry Terms | N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide;NS 398;NS-398;NS398 |
Molecular Weight | 314.36 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2225832 | Certificate of Analysis | Dec 12, 2022 | N274713 |
B2225807 | Certificate of Analysis | Dec 12, 2022 | N274713 |
B2225820 | Certificate of Analysis | Dec 12, 2022 | N274713 |
B2225821 | Certificate of Analysis | Dec 12, 2022 | N274713 |
B2225373 | Certificate of Analysis | Dec 12, 2022 | N274713 |
B2225391 | Certificate of Analysis | Dec 12, 2022 | N274713 |
Solubility | Soluble in DMSO to 100 mM;Chloroform (Slightly), methanol (Slightly) |
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Melt Point(°C) | 139 °C |
1. Inagaki M, Tsuri T, Jyoyama H, Ono T, Yamada K, Kobayashi M, Hori Y, Arimura A, Yasui K, Ohno K et al.. (2000) Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.. J Med Chem, 43 (10): (2040-8). [PMID:10821716] |
2. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, Otomo S. (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.. Gen Pharmacol, 24 (1): (105-10). [PMID:8482483] |
3. Cong J et al.. (2021) Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice.. Front Cell Neurosci, 15 (772549). [PMID:34887729] |
4. Bagayoko S et al.. (2021) Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.. PLoS Pathog, 17 (9): (e1009927). [PMID:34516571] |
5. Ishihara E et al.. (2020) Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition.. Genes Cells, 25 (3): (197-214). [PMID:31989743] |