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NS 9283 - ≥99%(HPLC), high purity , CAS No.913830-15-6, Allosteric modulator of nicotinic acetylcholine receptor α4 subunit

Moligand™
≥99%(HPLC)

CAS#: 913830-15-6
Formula: C₁₄H₈N₄O
Molecular Weight: 248.24
PubChem CID: 11998180

Item Number

N288399

Grouped product items
SKU	Size	Availability	Price
N288399-5mg	5mg	In stock	$124.90
N288399-10mg	10mg	In stock	$190.90
N288399-25mg	25mg	In stock	$429.90
N288399-50mg	50mg	In stock	$801.90

Positive allosteric modulator of α4β2 nAChRs

View related series

nicotinic acetylcholine receptor α4 subunit Allosteric modulator

Basic Description

Synonyms	3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Positive allosteric modulator ofα4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without effecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Display
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of nicotinic acetylcholine receptor α4 subunit

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA3 Tclin Neuronal acetylcholine receptor subunit alpha-3 0 Activities

Discover Target: CHRNA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNB2 Tclin Neuronal acetylcholine receptor subunit beta-2 0 Activities

Discover Target: CHRNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA4 Tclin Neuronal acetylcholine receptor subunit alpha-4 0 Activities

Discover Target: CHRNA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)benzonitrile
INCHI	InChI=1S/C14H8N4O/c15-8-10-3-1-4-11(7-10)14-17-13(18-19-14)12-5-2-6-16-9-12/h1-7,9H
InChi Key	HGFXDSQLRSWUBO-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)C2=NC(=NO2)C3=CN=CC=C3)C#N
Isomeric SMILES	C1=CC(=CC(=C1)C2=NC(=NO2)C3=CN=CC=C3)C#N
PubChem CID	11998180
Molecular Weight	248.24

PubChem CID

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
K2229893	Certificate of Analysis	Oct 21, 2022	N288399
K2229894	Certificate of Analysis	Oct 21, 2022	N288399
K2229895	Certificate of Analysis	Oct 21, 2022	N288399
K2229896	Certificate of Analysis	Oct 21, 2022	N288399

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P362:Take off contaminated clothing. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

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