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NS 9283 - ≥99%(HPLC), high purity , CAS No.913830-15-6, Allosteric modulator of nicotinic acetylcholine receptor α4 subunit
Positive allosteric modulator of α4β2 nAChRs
Basic Description Synonyms 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile Specifications & Purity Moligand™, ≥99%(HPLC) Biochemical and Physiological Mechanisms Positive allosteric modulator ofα4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without effecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Display Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of nicotinic acetylcholine receptor α4 subunit
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)benzonitrile INCHI InChI=1S/C14H8N4O/c15-8-10-3-1-4-11(7-10)14-17-13(18-19-14)12-5-2-6-16-9-12/h1-7,9H InChi Key HGFXDSQLRSWUBO-UHFFFAOYSA-N Canonical SMILES C1=CC(=CC(=C1)C2=NC(=NO2)C3=CN=CC=C3)C#N Isomeric SMILES C1=CC(=CC(=C1)C2=NC(=NO2)C3=CN=CC=C3)C#N PubChem CID 11998180 Molecular Weight 248.24
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 12.41, Max Conc. mM: 50; Solvent:1eq. HCl, Max Conc. mg/mL: 4.96, Max Conc. mM: 20
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P362: Take off contaminated clothing.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
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K2229893