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Transmembrane Transporters
Voltage-gated ion channels
Potassium channels
NS6180 , CAS No.N612405, Channel blocker of K Ca3.1

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NS6180 , CAS No.N612405, Channel blocker of K Ca3.1

Moligand™

PubChem CID: 11837221

Item Number

N612405

Grouped product items
SKU	Size	Availability	Price	Qty
N612405-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N612405-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

KCa3.1 Channel blocker

Basic Description

Synonyms	ns6180 \| 353262-04-1 \| NS-6180 \| 4-(3-(trifluoromethyl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one \| NS 6180 \| 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one \| 4-[[3-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one \| AI-204/31722013 \| GTPL9318 \| CH
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of K Ca3.1

Associated Targets(Human)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[[3-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one
INCHI	InChI=1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
InChi Key	ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Canonical SMILES	O=C1CSc2c(N1Cc1cccc(c1)C(F)(F)F)cccc2
Isomeric SMILES	C1C(=O)N(C2=CC=CC=C2S1)CC3=CC(=CC=C3)C(F)(F)F
PubChem CID	11837221

Database links

PubChem CID	11837221

Certificates

Certificate of Analysis(COA)

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References

1. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H et al.. (2013) NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.. Br J Pharmacol, 168 (2): (432-44). [PMID:22891655]

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