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NS6180 , CAS No.N612405, Channel blocker of K Ca3.1

Item Number

N612405

Grouped product items
SKU	Size	Availability	Price	Qty
N612405-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N612405-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	ns6180\|353262-04-1\|NS-6180\|4-(3-(trifluoromethyl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one\|NS 6180\|4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one\|4-[[3-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one\|AI-204/31722013\|GTPL9318\|CH
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of K Ca3.1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	4-[[3-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one
INCHI	InChI=1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
InChi Key	ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Canonical SMILES	O=C1CSc2c(N1Cc1cccc(c1)C(F)(F)F)cccc2
Isomeric SMILES	C1C(=O)N(C2=CC=CC=C2S1)CC3=CC(=CC=C3)C(F)(F)F
PubChem CID	11837221

PubChem CID	11837221

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1. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H et al.. (2013) NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.. Br J Pharmacol, 168 (2): (432-44). [PMID:22891655]

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