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Ligand-gated ion channels
NS6740 , CAS No.N612406, Agonist of nicotinic acetylcholine receptor α7 subunit

NS6740 , CAS No.N612406, Agonist of nicotinic acetylcholine receptor α7 subunit

Item Number

N612406

Grouped product items
SKU	Size	Availability	Price	Qty
N612406-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
N612406-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	A-793394;A793394;NS-6740
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of nicotinic acetylcholine receptor α7 subunit

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methanone
INCHI	InChI=1S/C19H19F3N2O2/c20-19(21,22)14-3-1-2-13(12-14)16-4-5-17(26-16)18(25)24-11-10-23-8-6-15(24)7-9-23/h1-5,12,15H,6-11H2
InChi Key	VSOWCIMCDKXVRC-UHFFFAOYSA-N
Canonical SMILES	O=C(N1CCN2CCC1CC2)c1ccc(o1)c1cccc(c1)C(F)(F)F
Isomeric SMILES	C1CN2CCC1N(CC2)C(=O)C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F
PubChem CID	10021664

PubChem CID	10021664
ChEMBL Ligand	CHEMBL2380804

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1. Briggs CA, Grønlien JH, Curzon P, Timmermann DB, Ween H, Thorin-Hagene K, Kerr P, Anderson DJ, Malysz J, Dyhring T et al.. (2009) Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.. Br J Pharmacol, 158 (6): (1486-94). [PMID:19845675]
2. Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.. Neuropharmacology, 91 (3): (34-42). [PMID:25497451]

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