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NS6740 , CAS No.N612406, Agonist of nicotinic acetylcholine receptor α7 subunit
Basic Description
| Synonyms | A-793394;A793394;NS-6740 |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | AGONIST |
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| Mechanism of action | Agonist of nicotinic acetylcholine receptor α7 subunit |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methanone |
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| INCHI | InChI=1S/C19H19F3N2O2/c20-19(21,22)14-3-1-2-13(12-14)16-4-5-17(26-16)18(25)24-11-10-23-8-6-15(24)7-9-23/h1-5,12,15H,6-11H2 |
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| InChi Key | VSOWCIMCDKXVRC-UHFFFAOYSA-N |
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| Canonical SMILES | O=C(N1CCN2CCC1CC2)c1ccc(o1)c1cccc(c1)C(F)(F)F |
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| Isomeric SMILES | C1CN2CCC1N(CC2)C(=O)C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F |
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| PubChem CID | 10021664 |
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References
| 1. Briggs CA, Grønlien JH, Curzon P, Timmermann DB, Ween H, Thorin-Hagene K, Kerr P, Anderson DJ, Malysz J, Dyhring T et al.. (2009) Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.. Br J Pharmacol, 158 (6): (1486-94). [PMID:19845675] [10.1021/op500134e] |
| 2. Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.. Neuropharmacology, 91 (13): (34-42). [PMID:25497451] [10.1021/op500134e] |
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