NSC 405020 - ≥98%, high purity , CAS No.7497-07-6

Item Number

N129358

Grouped product items
SKU	Size	Availability	Price
N129358-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$77.90
N129358-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$286.90
N129358-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,291.90
N129358-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,649.90
N129358-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$20,922.90

Non-catalytic MT1-MMP inhibitor

Basic Description

Synonyms	NSC 405020\|7497-07-6\|3,4-dichloro-N-(pentan-2-yl)benzamide\|3,4-dichloro-N-pentan-2-ylbenzamide\|NSC-405020\|NSC405020\|3,4-Dichloro-N-(1-Methylbutyl)benza-Mide\|CHEMBL4303335\|STK029746\|3,4-Dichloro-N-(1-methylbutyl)benzamide\|DTXSID80323865\|EX-A190\|HMS3653L08\|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	NSC405020 is a PEX inhibitor targeting the PEX domain of MT1-MMP that repressed tumor growth and caused a fibrotic DPEX-like tumor phenotype in vivo. NSC405020 does not inhibit the catalytic activity of MMP-2.MT1-MMP (Membrane type-1 matrix metalloprotein
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3,4-dichloro-N-pentan-2-ylbenzamide
INCHI	InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
InChi Key	ARDYECYBETXQFD-UHFFFAOYSA-N
Canonical SMILES	CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl
Isomeric SMILES	CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl
PubChem CID	346721
Molecular Weight	260.16

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.

Solution Calculators

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Basic Description