NSC 663284 (DA3003-1) - ≥98%, high purity , CAS No.383907-43-5

  • ≥98%
Item Number
N275722
Grouped product items
SKUSizeAvailabilityPrice Qty
N275722-1mg
1mg
In stock
$28.90
N275722-5mg
5mg
In stock
$116.90
N275722-10mg
10mg
In stock
$207.90
N275722-25mg
25mg
In stock
$430.90
N275722-50mg
50mg
In stock
$770.90

Discover NSC 663284 (DA3003-1) by Aladdin Scientific in ≥98% for only $28.90. Available - in Ligands at Aladdin Scientific. Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor Tags: .

Basic Description

SynonymsNCGC00092289-02 | 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione | NCI60_021732 | 5,6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]- | NSC663284 | NSC-663284 | A13524 | CHEBI:92053 | DTXSID50327512 | MS-24764 | CY8W2F69MW | HMS3412L16 | DA-3003-
Specifications & Purity≥98%
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.


product description:

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM)


application:

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.


Associated Targets(Human)

KMT5A Tchem N-lysine methyltransferase KMT5A (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDC25A Tchem M-phase inducer phosphatase 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDC25B Tchem M-phase inducer phosphatase 2 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDC25C Tchem M-phase inducer phosphatase 3 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione
INCHI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChi Key BMKPVDQDJQWBPD-UHFFFAOYSA-N
Canonical SMILES C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
Isomeric SMILES C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
PubChem CID 379077
Molecular Weight 321.76

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
I2227740Certificate of AnalysisJul 19, 2023 N275722
I2227505Certificate of AnalysisJul 13, 2023 N275722
I2227544Certificate of AnalysisJul 13, 2023 N275722
I2227556Certificate of AnalysisJul 13, 2023 N275722
I2227504Certificate of AnalysisAug 09, 2022 N275722

Chemical and Physical Properties

SolubilitySoluble in ethanol to 50 mM and in DMSO to 50 mM
SensitivityLight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

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Solution Calculators