NSC 663284 (DA3003-1) - ≥98%, high purity , CAS No.383907-43-5

Item Number

N275722

• Synonyms: 383907-43-5 | NSC 663284 | NSC-663284 | DA-3003-1 | 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione | NSC663284 | SPS8I1 | 6-chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione | 6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione | CY8W2F69MW | 6-C
• Specifications & Purity: ≥98%
• Storage Temp: Protected from light,Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads

Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

product description：

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM)

application：

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.