Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
N275722-1mg | 1mg | In stock | $28.90 | |
N275722-5mg | 5mg | In stock | $116.90 | |
N275722-10mg | 10mg | In stock | $207.90 | |
N275722-25mg | 25mg | In stock | $430.90 | |
N275722-50mg | 50mg | In stock | $770.90 |
Discover NSC 663284 (DA3003-1) by Aladdin Scientific in ≥98% for only $28.90. Available - in Ligands at Aladdin Scientific. Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor Tags: .
Synonyms | NCGC00092289-02 | 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione | NCI60_021732 | 5,6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]- | NSC663284 | NSC-663284 | A13524 | CHEBI:92053 | DTXSID50327512 | MS-24764 | CY8W2F69MW | HMS3412L16 | DA-3003- |
---|---|
Specifications & Purity | ≥98% |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. product description: NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM) application: NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione |
---|---|
INCHI | InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
InChi Key | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
Canonical SMILES | C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl |
Isomeric SMILES | C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl |
PubChem CID | 379077 |
Molecular Weight | 321.76 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2227740 | Certificate of Analysis | Jul 19, 2023 | N275722 |
I2227505 | Certificate of Analysis | Jul 13, 2023 | N275722 |
I2227544 | Certificate of Analysis | Jul 13, 2023 | N275722 |
I2227556 | Certificate of Analysis | Jul 13, 2023 | N275722 |
I2227504 | Certificate of Analysis | Aug 09, 2022 | N275722 |
Solubility | Soluble in ethanol to 50 mM and in DMSO to 50 mM |
---|---|
Sensitivity | Light sensitive |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |