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NSC727447 - 98% (HPLC), high purity , CAS No.40106-12-5

≥98%(HPLC)

CAS#: 40106-12-5
Formula: C₁₀H₁₄N₂OS
Molecular Weight: 210.3
MDL number: MFCD00622214
PubChem CID: 2997881

Item Number

N170153

Grouped product items
SKU	Size	Availability	Price
N170153-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$10.90
N170153-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$43.90
N170153-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$144.90

Basic Description

Synonyms	40106-12-5\|2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide\|2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta-[b]thiophene-3-carboxamide\|NSC727447\|2-amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide\|MFCD00622214\|SMR000066289\|MLS000056922\|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H.
Storage Temp	Room temperature
Shipped In	Normal

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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GNAS Tbio Protein ALEX 0 Activities

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ANO1 Tclin Anoctamin-1 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
INCHI	InChI=1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
InChi Key	LULYZYNTDPUEKK-UHFFFAOYSA-N
Canonical SMILES	C1CCC2=C(CC1)SC(=C2C(=O)N)N
Isomeric SMILES	C1CCC2=C(CC1)SC(=C2C(=O)N)N
WGK Germany	3
PubChem CID	2997881
Molecular Weight	210.3

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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