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NT-proBNP Mouse mAb - Primary antibody, for ELISA,CLIA,GICA,Detection antibody,FIA various applications, from Human, generated in Mouse, specific to NT-proBNP, IgG1

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Validated
  • 8.66mg/mL
Features and benefits
  • Short Overview:

    mAb(1H2); Mouse anti Human NT-proBNP antibody; Detection antibody, ELISA, CLIA, GICA, FIA; Unconjugated

  • Application: ELISA,CLIA,GICA,Detection antibody,FIA
  • Species reactivity(Reacts with): Human
  • Isotype: IgG1
    Application:
  • CLIA
  • Detection Antibody
  • ELISA
  • FIA
  • GICA
Item Number
Ab007709
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab007709-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$26.90
Ab007709-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
Ab007709-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$105.90
Ab007709-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$774.90

mAb(1H2); Mouse anti Human NT-proBNP antibody; Detection antibody, ELISA, CLIA, GICA, FIA; Unconjugated

Basic Description

Product NameNT-proBNP Mouse mAb - Primary antibody, for ELISA,CLIA,GICA,Detection antibody,FIA various applications, from Human, generated in Mouse, specific to NT-proBNP, IgG1
SynonymsANFB_HUMAN antibody; BNP antibody; BNP(1-32) antibody; BNP(5-29) antibody; BNP-32 antibody; Brain type natriuretic peptide antibody; Gamma brain natriuretic peptide antibody; Gamma-brain natriuretic peptide antibody; Natriuretic peptide precursor B antibo
Specifications & PurityExactAb™, Validated, Carrier Free, Azide Free, 8.66mg/mL
Host SpeciesMouse
Host speciesMouse
SpecificityNT-proBNP
ApplicationELISA,CLIA,GICA,Detection antibody,FIA
ImmunogenNT-proBNP antigen (His27-His134)
Epitope27-31aa
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Validated
Product Description

Application
Detection antibody
ELISA: 1μg/ml;
CLIA: 1μg/ml;
GICA/FIA: 1mg/ml;

Protein function
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Product Properties

Antibody TypePrimary antibody
ClonalityMonoclonal antibodies
IsotypeIgG1
SDS-PAGE150kDa
Purification MethodCaprylic acid precipitation
Matched Pairs[Ab008412] Recombinant NT-proBNP Antibody as Capture antibody in ELISA, CLIA
SourceHybridoma supernatant
FormLiquid
Concentration8.66mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20±5℃ for three years. Avoid freeze/thaw.

Images

NT-proBNP Mouse mAb (Ab007709)-Binding ELISA
The binding activity of NT-proBNP Mouse mAb with NT-proBNP antigen. 

NT-proBNP Standard Curve with Antibody Pair (Ab008412 & Ab007709) in CLIA

· Capture antibody: Recombinant NT-proBNP Antibody (Ab008412) at 1.0 μg/mL.

· Detection antibody: NT-proBNP Mouse mAb (Ab007709) at 1.0 μg/mL.

· Linear Range: 5-35000 pg/mL, R ≥ 0.99.

NT-proBNP Standard Curve with Antibody Pair (Ab008412 & Ab007709) in FLFIA

· Capture antibody: Recombinant NT-proBNP Antibody (Ab008412) at 1.0 mg/mL.

· Detection antibody: NT-proBNP Mouse mAb (Ab007709) at 1.0 mg/mL. 

· Linear Range: 0-35000 pg/mL, LLOD: 50 pg/mL.

Associated Targets

GCSAM Tbio Germinal center-associated signaling and motility protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NPPB Tbio Natriuretic peptides B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
ELISA

1 μg/mL

CLIA

1 μg/mL

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0600291Certificate of AnalysisJun 07, 2023 Ab007709
ZJ23F0600290Certificate of AnalysisJun 07, 2023 Ab007709

Related Documents

References

1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al..  (2004)  The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)..  Genome Res,  14  (10B): (2121-7).  [PMID:15489334]
2. Koller, K J KJ and 6 more authors..  (1991)  Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)..  Science (New York, N.Y.),    (5):   [PMID:1672777]
3. Kambayashi, Y Y and 8 more authors..  (1990)  Isolation and sequence determination of human brain natriuretic peptide in human atrium..  FEBS letters,    (1):   [PMID:2136732]
4. Hino, J J, Tateyama, H H, Minamino, N N, Kangawa, K K and Matsuo, H H..  (1990)  Isolation and identification of human brain natriuretic peptides in cardiac atrium..  Biochemical and biophysical research communications,    (16):   [PMID:2138890]
5. Sudoh, T T and 5 more authors..  (1989)  Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide..  Biochemical and biophysical research communications,    (31):   [PMID:2522777]
6. Seilhamer, J J JJ and 6 more authors..  (1989)  Human and canine gene homologs of porcine brain natriuretic peptide..  Biochemical and biophysical research communications,    (15):   [PMID:2597152]
7. Jensen, K T KT, Carstens, J J and Pedersen, E B EB..  (1998)  Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans..  The American journal of physiology,      [PMID:9458824]
8. Yan, W W, Wu, F F, Morser, J J and Wu, Q Q..  (2000)  Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme..  Proceedings of the National Academy of Sciences of the United States of America,    (18):   [PMID:10880574]
9. Ohta, Y Y and 12 more authors..  (2000)  Carvedilol enhances atrial and brain natriuretic peptide mRNA expression and release in rat heart..  Journal of cardiovascular pharmacology,      [PMID:11206715]
10. Richards, A M AM and 9 more authors..  (2001)  Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. Australia-New Zealand Heart Failure Group..  Journal of the American College of Cardiology,    (1):   [PMID:11401111]
11. Frantz, Robert P RP and 11 more authors..  (2005)  Carvedilol therapy is associated with a sustained decline in brain natriuretic peptide levels in patients with congestive heart failure..  American heart journal,      [PMID:15864245]
12. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,    (18):   [PMID:16710414]
13. He, Xiao-lin XL, Dukkipati, Abhiram A and Garcia, K Christopher KC..  (2006)  Structural determinants of natriuretic peptide receptor specificity and degeneracy..  Journal of molecular biology,    (25):   [PMID:16870210]
14. Lam, Carolyn S P CS, Burnett, John C JC, Costello-Boerrigter, Lisa L, Rodeheffer, Richard J RJ and Redfield, Margaret M MM..  (2007)  Alternate circulating pro-B-type natriuretic peptide and B-type natriuretic peptide forms in the general population..  Journal of the American College of Cardiology,    (20):   [PMID:17367664]
15. Ralat, Luis A LA and 6 more authors..  (2011)  Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response..  The Journal of biological chemistry,    (11):   [PMID:21098034]
16. Keane, Fiona M FM, Nadvi, Naveed A NA, Yao, Tsun-Wen TW and Gorrell, Mark D MD..  (2011)  Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α..  The FEBS journal,      [PMID:21314817]
17. Peng, Jianhao J and 5 more authors..  (2011)  Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes..  Biochemical and biophysical research communications,    (5):   [PMID:21763278]
18. Huntley, Brenda K and 5 more authors..  (2015)  Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure..  Circulation. Heart failure,      [PMID:25339504]

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