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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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N647339-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $420.90 | |
N647339-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $600.90 | |
N647339-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,800.90 | |
N647339-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,520.90 |
Specifications & Purity | ≥96% |
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Biochemical and Physiological Mechanisms | NU6300 is a covalent, irreversible and ATP-competitive CDK2 inhibitor with an IC 50 value of 0.16 μM. NU6300 can be used for the research of eukaryotic cell cycle- and transcription-related. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | NU6300 is a covalent, irreversible and ATP-competitive CDK2 inhibitor with an IC 50 value of 0.16 μM. NU6300 can be used for the research of eukaryotic cell cycle- and transcription-related In Vitro NU6300 (50 μM; 0-1 hour) covalently modifies and irreversible inhibits CDK2. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: SKUT-1B cells Concentration: 50 μM Incubation Time: 0-1 hour Result: Affected retinoblastoma tumor suppressor protein (Rb) phosphorylation in SKUT-1B cells and covalently binded with CDK2. Form:Solid IC50& Target:CDK2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 6-(cyclohexylmethoxy)-N-(4-ethenylsulfonylphenyl)-7H-purin-2-amine |
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INCHI | InChI=1S/C20H23N5O3S/c1-2-29(26,27)16-10-8-15(9-11-16)23-20-24-18-17(21-13-22-18)19(25-20)28-12-14-6-4-3-5-7-14/h2,8-11,13-14H,1,3-7,12H2,(H2,21,22,23,24,25) |
InChi Key | KGWSQGUVJUGIPF-UHFFFAOYSA-N |
Canonical SMILES | C=CS(=O)(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3 |
Isomeric SMILES | C=CS(=O)(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3 |
PubChem CID | 118704754 |
Molecular Weight | 413.49 |
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Solubility | DMSO : ≥ 32 mg/mL (77.39 mM) |
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