NU7026 - ≥98%, high purity , CAS No.154447-35-5, Inhibitor of protein kinase; DNA-activated; catalytic subunit

Item Number

N129741

• Synonyms: 2-(Morpholin-4-yl)-benzo[h]chromen-4-one | 2-(morpholin-4-yl)benzo[h]chromen-4-one | CCG-206743 | HMS3675M22 | EC-000.2421 | NU 7026 | BCP04736 | BDBM50098126 | HSCI1_000223 | BCP29553 | NU-7026 | 2-MORPHOLINO-4H-BENZO(H)CHROMEN-4-ONE | AKOS015994580 | 2-
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage r
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of protein kinase; DNA-activated; catalytic subunit
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.
An antiproliferative agent, and inhibitor of DNA-PK.